Mueller-matrix-based polarization imaging and quantitative assessment of optically anisotropic polycrystalline networks

Igor Meglinski; Mariia Borovkova; Larysa Trifonyuk; Volodymyr Ushenko; Olexander Dubolazov; Oleg Vanchulyak; George Bodnar; Yurii Ushenko; Olena Olar; Olexander Ushenko; Michael Sakhnovskiy; Alexander Bykov

doi:10.1371/journal.pone.0214494

Mueller-matrix-based polarization imaging and quantitative assessment of optically anisotropic polycrystalline networks

Igor Meglinski^*, Mariia Borovkova, Larysa Trifonyuk, Volodymyr Ushenko, Olexander Dubolazov, Oleg Vanchulyak, George Bodnar, Yurii Ushenko, Olena Olar, Olexander Ushenko, Michael Sakhnovskiy, Alexander Bykov

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We introduce a Mueller-matrix imaging polarization-based approach for the quantitative digital screening of the polycrystalline structure of fibrillary-based biological tissues in vitro. The morphometric evaluation of histological sections of myocardium was performed utilizing the high-order statistical moments calculated based on the spatial distribution of linear and circular birefringence and dichroism obtained experimentally. We demonstrate that spatial distributions of phase of light and optical anisotropy of scattering inherent to fibrillar networks of myocardium at different necrotic stages can be effectively used as a quantitative marker of stages of myosin fibril degradation. Processing the images of phase of light scattered in biological tissues with high order statistical analysis provides a functional tool for the quantitative characterization of necrotic conditions of the myocardium.

Original language	English
Article number	e0214494
Journal	PLoS ONE
Volume	14
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0214494
Publication status	Published - 16 May 2019

Bibliographical note

© 2019 Borovkova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Meglinski, I., Borovkova, M., Trifonyuk, L., Ushenko, V., Dubolazov, O., Vanchulyak, O., Bodnar, G., Ushenko, Y., Olar, O., Ushenko, O., Sakhnovskiy, M., & Bykov, A. (2019). Mueller-matrix-based polarization imaging and quantitative assessment of optically anisotropic polycrystalline networks. PLoS ONE, 14(5), Article e0214494. https://doi.org/10.1371/journal.pone.0214494

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abstract = "We introduce a Mueller-matrix imaging polarization-based approach for the quantitative digital screening of the polycrystalline structure of fibrillary-based biological tissues in vitro. The morphometric evaluation of histological sections of myocardium was performed utilizing the high-order statistical moments calculated based on the spatial distribution of linear and circular birefringence and dichroism obtained experimentally. We demonstrate that spatial distributions of phase of light and optical anisotropy of scattering inherent to fibrillar networks of myocardium at different necrotic stages can be effectively used as a quantitative marker of stages of myosin fibril degradation. Processing the images of phase of light scattered in biological tissues with high order statistical analysis provides a functional tool for the quantitative characterization of necrotic conditions of the myocardium.",

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AU - Meglinski, Igor

AU - Borovkova, Mariia

AU - Trifonyuk, Larysa

AU - Ushenko, Volodymyr

AU - Dubolazov, Olexander

AU - Vanchulyak, Oleg

AU - Bodnar, George

AU - Ushenko, Yurii

AU - Olar, Olena

AU - Ushenko, Olexander

AU - Sakhnovskiy, Michael

AU - Bykov, Alexander

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Y1 - 2019/5/16

N2 - We introduce a Mueller-matrix imaging polarization-based approach for the quantitative digital screening of the polycrystalline structure of fibrillary-based biological tissues in vitro. The morphometric evaluation of histological sections of myocardium was performed utilizing the high-order statistical moments calculated based on the spatial distribution of linear and circular birefringence and dichroism obtained experimentally. We demonstrate that spatial distributions of phase of light and optical anisotropy of scattering inherent to fibrillar networks of myocardium at different necrotic stages can be effectively used as a quantitative marker of stages of myosin fibril degradation. Processing the images of phase of light scattered in biological tissues with high order statistical analysis provides a functional tool for the quantitative characterization of necrotic conditions of the myocardium.

AB - We introduce a Mueller-matrix imaging polarization-based approach for the quantitative digital screening of the polycrystalline structure of fibrillary-based biological tissues in vitro. The morphometric evaluation of histological sections of myocardium was performed utilizing the high-order statistical moments calculated based on the spatial distribution of linear and circular birefringence and dichroism obtained experimentally. We demonstrate that spatial distributions of phase of light and optical anisotropy of scattering inherent to fibrillar networks of myocardium at different necrotic stages can be effectively used as a quantitative marker of stages of myosin fibril degradation. Processing the images of phase of light scattered in biological tissues with high order statistical analysis provides a functional tool for the quantitative characterization of necrotic conditions of the myocardium.

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JO - PLoS ONE

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Mueller-matrix-based polarization imaging and quantitative assessment of optically anisotropic polycrystalline networks

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