Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin

B. Olalde; N. Garmendia; V. Sáez-Martínez; N. Argarate; P. Nooeaid; F. Morin; A.R. Boccaccini

doi:10.1016/j.msec.2013.05.002

Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin

B. Olalde
, N. Garmendia
, V. Sáez-Martínez
, N. Argarate
, P. Nooeaid
, F. Morin
, A.R. Boccaccini

Chemical Engineering & Applied Chemistry

Tecnalia
FideNa
Friedrich-Alexander-Universität Erlangen-Nürnberg

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass® derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid.

Original language	English
Pages (from-to)	3760-3767
Number of pages	8
Journal	Materials Science and Engineering C
Volume	33
Issue number	7
DOIs	https://doi.org/10.1016/j.msec.2013.05.002
Publication status	Published - Oct 2013

Keywords

scaffold
Bioglass®
vancomycin
microgel
PLGA
drug delivery

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10.1016/j.msec.2013.05.002

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Olalde, B., Garmendia, N., Sáez-Martínez, V., Argarate, N., Nooeaid, P., Morin, F., & Boccaccini, A. R. (2013). Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin. Materials Science and Engineering C, 33(7), 3760-3767. https://doi.org/10.1016/j.msec.2013.05.002

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abstract = "A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass{\textregistered} derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid.",

keywords = "scaffold, Bioglass{\textregistered}, vancomycin, microgel, PLGA, drug delivery",

author = "B. Olalde and N. Garmendia and V. S{\'a}ez-Mart{\'i}nez and N. Argarate and P. Nooeaid and F. Morin and A.R. Boccaccini",

year = "2013",

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doi = "10.1016/j.msec.2013.05.002",

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Olalde, B, Garmendia, N, Sáez-Martínez, V, Argarate, N, Nooeaid, P, Morin, F & Boccaccini, AR 2013, 'Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin', Materials Science and Engineering C, vol. 33, no. 7, pp. 3760-3767. https://doi.org/10.1016/j.msec.2013.05.002

Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin. / Olalde, B.; Garmendia, N.; Sáez-Martínez, V. et al.
In: Materials Science and Engineering C, Vol. 33, No. 7, 10.2013, p. 3760-3767.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin

AU - Olalde, B.

AU - Garmendia, N.

AU - Sáez-Martínez, V.

AU - Argarate, N.

AU - Nooeaid, P.

AU - Morin, F.

AU - Boccaccini, A.R.

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AB - A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass® derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid.

KW - scaffold

KW - Bioglass®

KW - vancomycin

KW - microgel

KW - PLGA

KW - drug delivery

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M3 - Article

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ER -

Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin

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