According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.
Bibliographical noteViktor V. Dremin, Evgeny A. Zherebtsov, Victor V. Sidorov, Alexander I. Krupatkin, Irina N. Makovik, Angelina I. Zherebtsova, Elena V. Zharkikh, Elena V. Potapova, Andrey V. Dunaev, Alexander A. Doronin, Alexander V. Bykov, Ilya E. Rafailov, Karina S. Litvinova, Sergei G. Sokolovski, Edik U. Rafailov, "Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus," Journal of Biomedical Optics 22(8), 085003 (19 August 2017).
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- advanced glycation end products
- diabetes mellitus
- diagnostic volume
- fluorescence spectroscopy
- laser Doppler flowmetry
- mitochondrial function