Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus

Viktor V. Dremin*, Evgeny A. Zherebtsov, Victor V. Sidorov, Alexander I. Krupatkin, Irina N. Makovik, Angelina I. Zherebtsova, Elena V. Zharkikh, Elena V. Potapova, Andrey V. Dunaev, Alexander A. Doronin, Alexander V. Bykov, Ilya E. Rafailov, Karina S. Litvinova, Sergei G. Sokolovski, Edik U. Rafailov

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.

Original languageEnglish
Article number085003
Number of pages8
JournalJournal of Biomedical Optics
Volume22
Issue number8
DOIs
Publication statusPublished - 19 Aug 2017

Fingerprint

diabetes mellitus
Medical problems
limbs
optical measurement
viability
ulcers
Tissue
blood
fluorescence
Blood
Fluorescence
Skin
stimulation
markers
stimuli
Microcirculation
heating
lasers
Heating
Lasers

Bibliographical note

Viktor V. Dremin, Evgeny A. Zherebtsov, Victor V. Sidorov, Alexander I. Krupatkin, Irina N. Makovik, Angelina I. Zherebtsova, Elena V. Zharkikh, Elena V. Potapova, Andrey V. Dunaev, Alexander A. Doronin, Alexander V. Bykov, Ilya E. Rafailov, Karina S. Litvinova, Sergei G. Sokolovski, Edik U. Rafailov, "Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus," Journal of Biomedical Optics 22(8), 085003 (19 August 2017).

Copyright 2017. Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

http://dx.doi.org/10.1117/1.JBO.22.8.085003

Keywords

  • advanced glycation end products
  • diabetes mellitus
  • diagnostic volume
  • fluorescence spectroscopy
  • laser Doppler flowmetry
  • metabolism
  • mitochondrial function

Cite this

Dremin, V. V., Zherebtsov, E. A., Sidorov, V. V., Krupatkin, A. I., Makovik, I. N., Zherebtsova, A. I., ... Rafailov, E. U. (2017). Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus. Journal of Biomedical Optics, 22(8), [085003]. https://doi.org/10.1117/1.JBO.22.8.085003
Dremin, Viktor V. ; Zherebtsov, Evgeny A. ; Sidorov, Victor V. ; Krupatkin, Alexander I. ; Makovik, Irina N. ; Zherebtsova, Angelina I. ; Zharkikh, Elena V. ; Potapova, Elena V. ; Dunaev, Andrey V. ; Doronin, Alexander A. ; Bykov, Alexander V. ; Rafailov, Ilya E. ; Litvinova, Karina S. ; Sokolovski, Sergei G. ; Rafailov, Edik U. / Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus. In: Journal of Biomedical Optics. 2017 ; Vol. 22, No. 8.
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Dremin, VV, Zherebtsov, EA, Sidorov, VV, Krupatkin, AI, Makovik, IN, Zherebtsova, AI, Zharkikh, EV, Potapova, EV, Dunaev, AV, Doronin, AA, Bykov, AV, Rafailov, IE, Litvinova, KS, Sokolovski, SG & Rafailov, EU 2017, 'Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus', Journal of Biomedical Optics, vol. 22, no. 8, 085003. https://doi.org/10.1117/1.JBO.22.8.085003

Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus. / Dremin, Viktor V.; Zherebtsov, Evgeny A.; Sidorov, Victor V.; Krupatkin, Alexander I.; Makovik, Irina N.; Zherebtsova, Angelina I.; Zharkikh, Elena V.; Potapova, Elena V.; Dunaev, Andrey V.; Doronin, Alexander A.; Bykov, Alexander V.; Rafailov, Ilya E.; Litvinova, Karina S.; Sokolovski, Sergei G.; Rafailov, Edik U.

In: Journal of Biomedical Optics, Vol. 22, No. 8, 085003, 19.08.2017.

Research output: Contribution to journalArticle

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T1 - Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus

AU - Dremin, Viktor V.

AU - Zherebtsov, Evgeny A.

AU - Sidorov, Victor V.

AU - Krupatkin, Alexander I.

AU - Makovik, Irina N.

AU - Zherebtsova, Angelina I.

AU - Zharkikh, Elena V.

AU - Potapova, Elena V.

AU - Dunaev, Andrey V.

AU - Doronin, Alexander A.

AU - Bykov, Alexander V.

AU - Rafailov, Ilya E.

AU - Litvinova, Karina S.

AU - Sokolovski, Sergei G.

AU - Rafailov, Edik U.

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PY - 2017/8/19

Y1 - 2017/8/19

N2 - According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.

AB - According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.

KW - advanced glycation end products

KW - diabetes mellitus

KW - diagnostic volume

KW - fluorescence spectroscopy

KW - laser Doppler flowmetry

KW - metabolism

KW - mitochondrial function

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Dremin VV, Zherebtsov EA, Sidorov VV, Krupatkin AI, Makovik IN, Zherebtsova AI et al. Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus. Journal of Biomedical Optics. 2017 Aug 19;22(8). 085003. https://doi.org/10.1117/1.JBO.22.8.085003