Multiple frequency functional connectivity in the hand somatosensory network: an EEG study

Camillo Porcaro, Gianluca Coppola, Francesco Pierelli, Stephano Seri, Giorgio Di Lorenzo, Leo Tomasevic, Carlo Salustri, Franca Tecchio

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the dynamics of communication within the primary somatosensory neuronal network. Methods: Multichannel EEG responses evoked by median nerve stimulation were recorded from six healthy participants. We investigated the directional connectivity of the evoked responses by assessing the Partial Directed Coherence (PDC) among five neuronal nodes (brainstem, thalamus and three in the primary sensorimotor cortex), which had been identified by using the Functional Source Separation (FSS) algorithm. We analyzed directional connectivity separately in the low (1-200. Hz, LF) and high (450-750. Hz, HF) frequency ranges. Results: LF forward connectivity showed peaks at 16, 20, 30 and 50. ms post-stimulus. An estimate of the strength of connectivity was modulated by feedback involving cortical and subcortical nodes. In HF, forward connectivity showed peaks at 20, 30 and 50. ms, with no apparent feedback-related strength changes. Conclusions: In this first non-invasive study in humans, we documented directional connectivity across subcortical and cortical somatosensory pathway, discriminating transmission properties within LF and HF ranges. Significance: The combined use of FSS and PDC in a simple protocol such as median nerve stimulation sheds light on how high and low frequency components of the somatosensory evoked response are functionally interrelated in sustaining somatosensory perception in healthy individuals. Thus, these components may potentially be explored as biomarkers of pathological conditions. © 2012 International Federation of Clinical Neurophysiology.

LanguageEnglish
Pages1216-1224
Number of pages9
JournalClinical Neurophysiology
Volume124
Issue number6
Early online date12 Jan 2013
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Median Nerve
Electroencephalography
Hand
Thalamus
Brain Stem
Healthy Volunteers
Biomarkers
Communication
Sensorimotor Cortex

Bibliographical note

Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Keywords

  • 600Hz
  • Electroencephalography (EEG)
  • Functional connectivity
  • Functional Source Separation (FSS)
  • Granger causality
  • High frequency oscillations (HFO)
  • Low frequency oscillations (LFO)
  • Partial Directed Coherence (PDC)
  • Somatosensory subcortical and primary cortical network

Cite this

Porcaro, C., Coppola, G., Pierelli, F., Seri, S., Di Lorenzo, G., Tomasevic, L., ... Tecchio, F. (2013). Multiple frequency functional connectivity in the hand somatosensory network: an EEG study. Clinical Neurophysiology , 124(6), 1216-1224. https://doi.org/10.1016/j.clinph.2012.12.004
Porcaro, Camillo ; Coppola, Gianluca ; Pierelli, Francesco ; Seri, Stephano ; Di Lorenzo, Giorgio ; Tomasevic, Leo ; Salustri, Carlo ; Tecchio, Franca. / Multiple frequency functional connectivity in the hand somatosensory network : an EEG study. In: Clinical Neurophysiology . 2013 ; Vol. 124, No. 6. pp. 1216-1224.
@article{9e9e7f9a3b6841f19f6f593c4d6e7e32,
title = "Multiple frequency functional connectivity in the hand somatosensory network: an EEG study",
abstract = "Objective: To investigate the dynamics of communication within the primary somatosensory neuronal network. Methods: Multichannel EEG responses evoked by median nerve stimulation were recorded from six healthy participants. We investigated the directional connectivity of the evoked responses by assessing the Partial Directed Coherence (PDC) among five neuronal nodes (brainstem, thalamus and three in the primary sensorimotor cortex), which had been identified by using the Functional Source Separation (FSS) algorithm. We analyzed directional connectivity separately in the low (1-200. Hz, LF) and high (450-750. Hz, HF) frequency ranges. Results: LF forward connectivity showed peaks at 16, 20, 30 and 50. ms post-stimulus. An estimate of the strength of connectivity was modulated by feedback involving cortical and subcortical nodes. In HF, forward connectivity showed peaks at 20, 30 and 50. ms, with no apparent feedback-related strength changes. Conclusions: In this first non-invasive study in humans, we documented directional connectivity across subcortical and cortical somatosensory pathway, discriminating transmission properties within LF and HF ranges. Significance: The combined use of FSS and PDC in a simple protocol such as median nerve stimulation sheds light on how high and low frequency components of the somatosensory evoked response are functionally interrelated in sustaining somatosensory perception in healthy individuals. Thus, these components may potentially be explored as biomarkers of pathological conditions. {\circledC} 2012 International Federation of Clinical Neurophysiology.",
keywords = "600Hz, Electroencephalography (EEG), Functional connectivity, Functional Source Separation (FSS), Granger causality, High frequency oscillations (HFO), Low frequency oscillations (LFO), Partial Directed Coherence (PDC), Somatosensory subcortical and primary cortical network",
author = "Camillo Porcaro and Gianluca Coppola and Francesco Pierelli and Stephano Seri and {Di Lorenzo}, Giorgio and Leo Tomasevic and Carlo Salustri and Franca Tecchio",
note = "Copyright {\circledC} 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.",
year = "2013",
month = "6",
doi = "10.1016/j.clinph.2012.12.004",
language = "English",
volume = "124",
pages = "1216--1224",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier",
number = "6",

}

Porcaro, C, Coppola, G, Pierelli, F, Seri, S, Di Lorenzo, G, Tomasevic, L, Salustri, C & Tecchio, F 2013, 'Multiple frequency functional connectivity in the hand somatosensory network: an EEG study' Clinical Neurophysiology , vol. 124, no. 6, pp. 1216-1224. https://doi.org/10.1016/j.clinph.2012.12.004

Multiple frequency functional connectivity in the hand somatosensory network : an EEG study. / Porcaro, Camillo; Coppola, Gianluca; Pierelli, Francesco; Seri, Stephano; Di Lorenzo, Giorgio; Tomasevic, Leo; Salustri, Carlo; Tecchio, Franca.

In: Clinical Neurophysiology , Vol. 124, No. 6, 06.2013, p. 1216-1224.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multiple frequency functional connectivity in the hand somatosensory network

T2 - Clinical Neurophysiology

AU - Porcaro, Camillo

AU - Coppola, Gianluca

AU - Pierelli, Francesco

AU - Seri, Stephano

AU - Di Lorenzo, Giorgio

AU - Tomasevic, Leo

AU - Salustri, Carlo

AU - Tecchio, Franca

N1 - Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

PY - 2013/6

Y1 - 2013/6

N2 - Objective: To investigate the dynamics of communication within the primary somatosensory neuronal network. Methods: Multichannel EEG responses evoked by median nerve stimulation were recorded from six healthy participants. We investigated the directional connectivity of the evoked responses by assessing the Partial Directed Coherence (PDC) among five neuronal nodes (brainstem, thalamus and three in the primary sensorimotor cortex), which had been identified by using the Functional Source Separation (FSS) algorithm. We analyzed directional connectivity separately in the low (1-200. Hz, LF) and high (450-750. Hz, HF) frequency ranges. Results: LF forward connectivity showed peaks at 16, 20, 30 and 50. ms post-stimulus. An estimate of the strength of connectivity was modulated by feedback involving cortical and subcortical nodes. In HF, forward connectivity showed peaks at 20, 30 and 50. ms, with no apparent feedback-related strength changes. Conclusions: In this first non-invasive study in humans, we documented directional connectivity across subcortical and cortical somatosensory pathway, discriminating transmission properties within LF and HF ranges. Significance: The combined use of FSS and PDC in a simple protocol such as median nerve stimulation sheds light on how high and low frequency components of the somatosensory evoked response are functionally interrelated in sustaining somatosensory perception in healthy individuals. Thus, these components may potentially be explored as biomarkers of pathological conditions. © 2012 International Federation of Clinical Neurophysiology.

AB - Objective: To investigate the dynamics of communication within the primary somatosensory neuronal network. Methods: Multichannel EEG responses evoked by median nerve stimulation were recorded from six healthy participants. We investigated the directional connectivity of the evoked responses by assessing the Partial Directed Coherence (PDC) among five neuronal nodes (brainstem, thalamus and three in the primary sensorimotor cortex), which had been identified by using the Functional Source Separation (FSS) algorithm. We analyzed directional connectivity separately in the low (1-200. Hz, LF) and high (450-750. Hz, HF) frequency ranges. Results: LF forward connectivity showed peaks at 16, 20, 30 and 50. ms post-stimulus. An estimate of the strength of connectivity was modulated by feedback involving cortical and subcortical nodes. In HF, forward connectivity showed peaks at 20, 30 and 50. ms, with no apparent feedback-related strength changes. Conclusions: In this first non-invasive study in humans, we documented directional connectivity across subcortical and cortical somatosensory pathway, discriminating transmission properties within LF and HF ranges. Significance: The combined use of FSS and PDC in a simple protocol such as median nerve stimulation sheds light on how high and low frequency components of the somatosensory evoked response are functionally interrelated in sustaining somatosensory perception in healthy individuals. Thus, these components may potentially be explored as biomarkers of pathological conditions. © 2012 International Federation of Clinical Neurophysiology.

KW - 600Hz

KW - Electroencephalography (EEG)

KW - Functional connectivity

KW - Functional Source Separation (FSS)

KW - Granger causality

KW - High frequency oscillations (HFO)

KW - Low frequency oscillations (LFO)

KW - Partial Directed Coherence (PDC)

KW - Somatosensory subcortical and primary cortical network

UR - http://www.scopus.com/inward/record.url?scp=84878109546&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2012.12.004

DO - 10.1016/j.clinph.2012.12.004

M3 - Article

VL - 124

SP - 1216

EP - 1224

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 6

ER -