The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.
Bibliographical noteNOTICE: this is the author’s version of a work that was accepted for publication in Journal of molecular and cellular cardiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Akki, A, Zhang, M, Murdoch, C, Brewer, A & Shah, AM, 'NADPH oxidase signaling and cardiac myocyte function' Journal of molecular and cellular cardiology, vol. 47, no. 1 (2009) DOI http://dx.doi.org/10.1016/j.yjmcc.2009.04.004
- NADPH oxidase
- cardiac myocytes