NADPH oxidase signaling and cardiac myocyte function

Ashwin Akki; Min Zhang; Colin Murdoch; Alison Brewer; Ajay M. Shah

doi:10.1016/j.yjmcc.2009.04.004

NADPH oxidase signaling and cardiac myocyte function

Ashwin Akki, Min Zhang, Colin Murdoch, Alison Brewer, Ajay M. Shah

Research output: Contribution to journal › Book/Film/Article review › peer-review

Abstract

The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.

Original language	English
Pages (from-to)	15-22
Number of pages	8
Journal	Journal of Molecular and Cellular Cardiology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/j.yjmcc.2009.04.004
Publication status	Published - Jul 2009

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Journal of molecular and cellular cardiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Akki, A, Zhang, M, Murdoch, C, Brewer, A & Shah, AM, 'NADPH oxidase signaling and cardiac myocyte function' Journal of molecular and cellular cardiology, vol. 47, no. 1 (2009) DOI http://dx.doi.org/10.1016/j.yjmcc.2009.04.004

Keywords

NADPH oxidase
Redox
remodeling
hypertrophy
contraction
signaling
cardiac myocytes

Access to Document

10.1016/j.yjmcc.2009.04.004

NADPH oxidase signaling and cardiac myocyte function
NOTICE: this is the author’s version of a work that was accepted for publication in Journal of molecular and cellular cardiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Akki, A, Zhang, M, Murdoch, C, Brewer, A & Shah, AM, 'NADPH oxidase signaling and cardiac myocyte function' Journal of molecular and cellular cardiology, vol. 47, no. 1 (2009) DOI http://dx.doi.org/10.1016/j.yjmcc.2009.04.004
Accepted author manuscript, 280 KB

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title = "NADPH oxidase signaling and cardiac myocyte function",

abstract = "The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.",

keywords = "NADPH oxidase, Redox, remodeling, hypertrophy, contraction, signaling, cardiac myocytes",

author = "Ashwin Akki and Min Zhang and Colin Murdoch and Alison Brewer and Shah, {Ajay M.}",

note = "NOTICE: this is the author{\textquoteright}s version of a work that was accepted for publication in Journal of molecular and cellular cardiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Akki, A, Zhang, M, Murdoch, C, Brewer, A & Shah, AM, 'NADPH oxidase signaling and cardiac myocyte function' Journal of molecular and cellular cardiology, vol. 47, no. 1 (2009) DOI http://dx.doi.org/10.1016/j.yjmcc.2009.04.004",

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AU - Zhang, Min

AU - Murdoch, Colin

AU - Brewer, Alison

AU - Shah, Ajay M.

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AB - The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.

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KW - Redox

KW - remodeling

KW - hypertrophy

KW - contraction

KW - signaling

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