Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration

Filipe V. Ferreira; Lucas P. Souza; Thais M. M. Martins; João H. Lopes; Bruno D. Mattos; Marcos Mariano; Ivanei F. Pinheiro; Thalita M. Valverde; Sébastien Livi; José A. Camilli; Alfredo M. Goes; Rubia F. Gouveia; Liliane M. F. Lona; Orlando J. Rojas

doi:10.1039/c9nr05383b

Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration

Filipe V. Ferreira, Lucas P. Souza, Thais M. M. Martins, João H. Lopes, Bruno D. Mattos, Marcos Mariano, Ivanei F. Pinheiro, Thalita M. Valverde, Sébastien Livi, José A. Camilli, Alfredo M. Goes, Rubia F. Gouveia, Liliane M. F. Lona, Orlando J. Rojas

Research output: Contribution to journal › Article › peer-review

Abstract

A major challenge exists in the preparation of scaffolds for bone regeneration, namely, achieving simultaneously bioactivity, biocompatibility, mechanical performance and simple manufacturing. Here, cellulose nanofibrils (CNF) are introduced for the preparation of scaffolds taking advantage of their biocompatibility and ability to form strong 3D porous networks from aqueous suspensions. CNF are made bioactive for bone formation through a simple and scalable strategy that achieves highly interconnected 3D networks. The resultant materials optimally combine morphological and mechanical features and facilitate hydroxyapatite formation while releasing essential ions for in vivo bone repair. The porosity and roughness of the scaffolds favor several cell functions while the ions act in the expression of genes associated with
cell differentiation. Ion release is found critical to enhance the production of the bone morphogenetic protein 2 (BMP-2) from cells within the fractured area, thus accelerating the in vivo bone repair. Systemic biocompatibility indicates no negative effects on vital organs such as the liver and kidneys. The results
pave the way towards a facile preparation of advanced, high performance CNF-based scaffolds for bone tissue engineering.

Original language	English
Pages (from-to)	19842-19849
Number of pages	8
Journal	Nanoscale
Volume	11
Issue number	42
Early online date	14 Aug 2019
DOIs	https://doi.org/10.1039/c9nr05383b
Publication status	Published - 14 Nov 2019

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title = "Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration",

abstract = "A major challenge exists in the preparation of scaffolds for bone regeneration, namely, achieving simultaneously bioactivity, biocompatibility, mechanical performance and simple manufacturing. Here, cellulose nanofibrils (CNF) are introduced for the preparation of scaffolds taking advantage of their biocompatibility and ability to form strong 3D porous networks from aqueous suspensions. CNF are made bioactive for bone formation through a simple and scalable strategy that achieves highly interconnected 3D networks. The resultant materials optimally combine morphological and mechanical features and facilitate hydroxyapatite formation while releasing essential ions for in vivo bone repair. The porosity and roughness of the scaffolds favor several cell functions while the ions act in the expression of genes associated withcell differentiation. Ion release is found critical to enhance the production of the bone morphogenetic protein 2 (BMP-2) from cells within the fractured area, thus accelerating the in vivo bone repair. Systemic biocompatibility indicates no negative effects on vital organs such as the liver and kidneys. The resultspave the way towards a facile preparation of advanced, high performance CNF-based scaffolds for bone tissue engineering.",

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AU - Ferreira, Filipe V.

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AU - Mattos, Bruno D.

AU - Mariano, Marcos

AU - Pinheiro, Ivanei F.

AU - Valverde, Thalita M.

AU - Livi, Sébastien

AU - Camilli, José A.

AU - Goes, Alfredo M.

AU - Gouveia, Rubia F.

AU - Lona, Liliane M. F.

AU - Rojas, Orlando J.

N1 - This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

PY - 2019/11/14

Y1 - 2019/11/14

N2 - A major challenge exists in the preparation of scaffolds for bone regeneration, namely, achieving simultaneously bioactivity, biocompatibility, mechanical performance and simple manufacturing. Here, cellulose nanofibrils (CNF) are introduced for the preparation of scaffolds taking advantage of their biocompatibility and ability to form strong 3D porous networks from aqueous suspensions. CNF are made bioactive for bone formation through a simple and scalable strategy that achieves highly interconnected 3D networks. The resultant materials optimally combine morphological and mechanical features and facilitate hydroxyapatite formation while releasing essential ions for in vivo bone repair. The porosity and roughness of the scaffolds favor several cell functions while the ions act in the expression of genes associated withcell differentiation. Ion release is found critical to enhance the production of the bone morphogenetic protein 2 (BMP-2) from cells within the fractured area, thus accelerating the in vivo bone repair. Systemic biocompatibility indicates no negative effects on vital organs such as the liver and kidneys. The resultspave the way towards a facile preparation of advanced, high performance CNF-based scaffolds for bone tissue engineering.

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Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration

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