Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1

Melissa Cudmore; Shakil Ahmad; Bahjat Al-Ani; Takeshi Fujisawa; Heather Coxall; Kunal Chudasama; Luke R. Devey; Stephen J. Wigmore; Allyah Abbas; Peter W. Hewett; Asif Ahmed

doi:10.1161/CIRCULATIONAHA.106.660134

Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1

Melissa Cudmore
, Shakil Ahmad
, Bahjat Al-Ani
, Takeshi Fujisawa
, Heather Coxall
, Kunal Chudasama
, Luke R. Devey
, Stephen J. Wigmore
, Allyah Abbas
, Peter W. Hewett
, Asif Ahmed

Research output: Contribution to journal › Article › peer-review

373 Citations (SciVal)

Abstract

Preeclampsia is characterized clinically by hypertension and proteinuria. Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 [VEGFR-1]) and soluble endoglin (sEng) are elevated in preeclampsia, and their administration to pregnant rats elicits preeclampsia-like symptoms. Heme oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO) exert protective effects against oxidative stimuli. Thus, we hypothesized that HO-1 upregulation may offer protection against preeclampsia by inhibiting sFlt-1 and sEng release.

Original language	English
Pages (from-to)	1789-1797
Number of pages	9
Journal	Circulation
Volume	115
Issue number	13
Early online date	26 Mar 2007
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.106.660134
Publication status	Published - 26 Mar 2007

Keywords

endothelium
endothelium-derived factors
heme oxygenase-1
preeclampsia
pregnancy
statins
angiogenesis

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10.1161/CIRCULATIONAHA.106.660134

Cite this

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title = "Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1",

abstract = "Preeclampsia is characterized clinically by hypertension and proteinuria. Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 [VEGFR-1]) and soluble endoglin (sEng) are elevated in preeclampsia, and their administration to pregnant rats elicits preeclampsia-like symptoms. Heme oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO) exert protective effects against oxidative stimuli. Thus, we hypothesized that HO-1 upregulation may offer protection against preeclampsia by inhibiting sFlt-1 and sEng release.",

keywords = "endothelium , endothelium-derived factors , heme oxygenase-1 , preeclampsia , pregnancy , statins , angiogenesis",

author = "Melissa Cudmore and Shakil Ahmad and Bahjat Al-Ani and Takeshi Fujisawa and Heather Coxall and Kunal Chudasama and Devey, \{Luke R.\} and Wigmore, \{Stephen J.\} and Allyah Abbas and Hewett, \{Peter W.\} and Asif Ahmed",

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doi = "10.1161/CIRCULATIONAHA.106.660134",

language = "English",

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TY - JOUR

T1 - Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1

AU - Cudmore, Melissa

AU - Ahmad, Shakil

AU - Al-Ani, Bahjat

AU - Fujisawa, Takeshi

AU - Coxall, Heather

AU - Chudasama, Kunal

AU - Devey, Luke R.

AU - Wigmore, Stephen J.

AU - Abbas, Allyah

AU - Hewett, Peter W.

AU - Ahmed, Asif

PY - 2007/3/26

Y1 - 2007/3/26

N2 - Preeclampsia is characterized clinically by hypertension and proteinuria. Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 [VEGFR-1]) and soluble endoglin (sEng) are elevated in preeclampsia, and their administration to pregnant rats elicits preeclampsia-like symptoms. Heme oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO) exert protective effects against oxidative stimuli. Thus, we hypothesized that HO-1 upregulation may offer protection against preeclampsia by inhibiting sFlt-1 and sEng release.

AB - Preeclampsia is characterized clinically by hypertension and proteinuria. Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 [VEGFR-1]) and soluble endoglin (sEng) are elevated in preeclampsia, and their administration to pregnant rats elicits preeclampsia-like symptoms. Heme oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO) exert protective effects against oxidative stimuli. Thus, we hypothesized that HO-1 upregulation may offer protection against preeclampsia by inhibiting sFlt-1 and sEng release.

KW - endothelium

KW - endothelium-derived factors

KW - heme oxygenase-1

KW - preeclampsia

KW - pregnancy

KW - statins

KW - angiogenesis

UR - http://circ.ahajournals.org/content/115/13/1789

U2 - 10.1161/CIRCULATIONAHA.106.660134

DO - 10.1161/CIRCULATIONAHA.106.660134

M3 - Article

C2 - 17389265

SN - 0009-7322

VL - 115

SP - 1789

EP - 1797

JO - Circulation

JF - Circulation

IS - 13

ER -

Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1

Abstract

Keywords

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