Neonatal seizures and post-neonatal epilepsy

a seven-year follow-up study

Francesco Pisani, Benedetta Piccolo, Gaetano Cantalupo, Cristiana Copioli, Carlo Fusco, Annalisa Pelosi, Carlo Alberto Tassinari, Stefano Seri

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Seizures are one of the most common symptoms of acute neurological disorders in newborns. This study aims at evaluating predictors of epilepsy in newborns with neonatal seizures.
METHODS: we recruited consecutively eighty-five neonates with repeated neonatal video-EEG-confirmed seizures between Jan 1999 and Dec 2004. The relationship between clinical, EEG and ultrasound data in neonatal period and the development of post-neonatal epilepsy was investigated at 7 years of age.
RESULTS: Fifteen patients (17.6%) developed post-neonatal epilepsy. Partial or no response to anticonvulsant therapy (OR 16.7, 95% CI: 1.8-155.8, p= .01; OR 47, 95% CI: 5.2-418.1, p<.01 respectively), severely abnormal cerebral ultrasound scan findings (OR: 5.4; 95% CI: 1.1-27.4; p<.04), severely abnormal EEG background activity (OR: 9.5; 95% CI: 1.6-54.2; p= .01) and the presence of status epilepticus (OR: 6.1; 95% CI: 1.8-20.3; p<.01) were found to be predictors of epilepsy. However, only the response to therapy seemed to be an independent predictor of post-neonatal epilepsy.
CONCLUSION: Neonatal seizures seem to be related to post-neonatal epilepsy. Recurrent and prolonged neonatal seizures may act on an epileptogenic substrate, causing further damage, which is responsible for the subsequent clinical expression of epilepsy.
Original languageEnglish
Pages (from-to)186–193
Number of pages8
JournalPediatric Research
Volume72
Issue number4
Early online date11 May 2012
DOIs
Publication statusPublished - Aug 2012

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Epilepsy
Seizures
Electroencephalography
Newborn Infant
Status Epilepticus
Nervous System Diseases
Anticonvulsants
Therapeutics

Cite this

Pisani, F., Piccolo, B., Cantalupo, G., Copioli, C., Fusco, C., Pelosi, A., ... Seri, S. (2012). Neonatal seizures and post-neonatal epilepsy: a seven-year follow-up study. Pediatric Research, 72(4), 186–193. https://doi.org/10.1038/pr.2012.66
Pisani, Francesco ; Piccolo, Benedetta ; Cantalupo, Gaetano ; Copioli, Cristiana ; Fusco, Carlo ; Pelosi, Annalisa ; Tassinari, Carlo Alberto ; Seri, Stefano. / Neonatal seizures and post-neonatal epilepsy : a seven-year follow-up study. In: Pediatric Research. 2012 ; Vol. 72, No. 4. pp. 186–193.
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Pisani, F, Piccolo, B, Cantalupo, G, Copioli, C, Fusco, C, Pelosi, A, Tassinari, CA & Seri, S 2012, 'Neonatal seizures and post-neonatal epilepsy: a seven-year follow-up study', Pediatric Research, vol. 72, no. 4, pp. 186–193. https://doi.org/10.1038/pr.2012.66

Neonatal seizures and post-neonatal epilepsy : a seven-year follow-up study. / Pisani, Francesco; Piccolo, Benedetta; Cantalupo, Gaetano; Copioli, Cristiana; Fusco, Carlo; Pelosi, Annalisa; Tassinari, Carlo Alberto; Seri, Stefano.

In: Pediatric Research, Vol. 72, No. 4, 08.2012, p. 186–193.

Research output: Contribution to journalArticle

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AU - Pisani, Francesco

AU - Piccolo, Benedetta

AU - Cantalupo, Gaetano

AU - Copioli, Cristiana

AU - Fusco, Carlo

AU - Pelosi, Annalisa

AU - Tassinari, Carlo Alberto

AU - Seri, Stefano

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N2 - BACKGROUND: Seizures are one of the most common symptoms of acute neurological disorders in newborns. This study aims at evaluating predictors of epilepsy in newborns with neonatal seizures.METHODS: we recruited consecutively eighty-five neonates with repeated neonatal video-EEG-confirmed seizures between Jan 1999 and Dec 2004. The relationship between clinical, EEG and ultrasound data in neonatal period and the development of post-neonatal epilepsy was investigated at 7 years of age.RESULTS: Fifteen patients (17.6%) developed post-neonatal epilepsy. Partial or no response to anticonvulsant therapy (OR 16.7, 95% CI: 1.8-155.8, p= .01; OR 47, 95% CI: 5.2-418.1, p<.01 respectively), severely abnormal cerebral ultrasound scan findings (OR: 5.4; 95% CI: 1.1-27.4; p<.04), severely abnormal EEG background activity (OR: 9.5; 95% CI: 1.6-54.2; p= .01) and the presence of status epilepticus (OR: 6.1; 95% CI: 1.8-20.3; p<.01) were found to be predictors of epilepsy. However, only the response to therapy seemed to be an independent predictor of post-neonatal epilepsy.CONCLUSION: Neonatal seizures seem to be related to post-neonatal epilepsy. Recurrent and prolonged neonatal seizures may act on an epileptogenic substrate, causing further damage, which is responsible for the subsequent clinical expression of epilepsy.

AB - BACKGROUND: Seizures are one of the most common symptoms of acute neurological disorders in newborns. This study aims at evaluating predictors of epilepsy in newborns with neonatal seizures.METHODS: we recruited consecutively eighty-five neonates with repeated neonatal video-EEG-confirmed seizures between Jan 1999 and Dec 2004. The relationship between clinical, EEG and ultrasound data in neonatal period and the development of post-neonatal epilepsy was investigated at 7 years of age.RESULTS: Fifteen patients (17.6%) developed post-neonatal epilepsy. Partial or no response to anticonvulsant therapy (OR 16.7, 95% CI: 1.8-155.8, p= .01; OR 47, 95% CI: 5.2-418.1, p<.01 respectively), severely abnormal cerebral ultrasound scan findings (OR: 5.4; 95% CI: 1.1-27.4; p<.04), severely abnormal EEG background activity (OR: 9.5; 95% CI: 1.6-54.2; p= .01) and the presence of status epilepticus (OR: 6.1; 95% CI: 1.8-20.3; p<.01) were found to be predictors of epilepsy. However, only the response to therapy seemed to be an independent predictor of post-neonatal epilepsy.CONCLUSION: Neonatal seizures seem to be related to post-neonatal epilepsy. Recurrent and prolonged neonatal seizures may act on an epileptogenic substrate, causing further damage, which is responsible for the subsequent clinical expression of epilepsy.

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Pisani F, Piccolo B, Cantalupo G, Copioli C, Fusco C, Pelosi A et al. Neonatal seizures and post-neonatal epilepsy: a seven-year follow-up study. Pediatric Research. 2012 Aug;72(4):186–193. https://doi.org/10.1038/pr.2012.66