Neurobehavioral consequences of prenatal antiepileptic drug exposure

Caroline Nadebaum, Vicki Anderson, Frank Vajda, David Reutens, Amanda Wood

Research output: Contribution to journalArticle

Abstract

Despite elevated rates of birth defects associated with prenatal antiepileptic drug exposure, pharmacotherapy is typically continued throughout pregnancy because of the risks posed to mother and child by recurrent seizures. Emerging data suggest that prenatal exposure to valproate or polytherapy may also be associated with increased risk of cognitive impairment. However, our understanding of the longer-term sequelae of prenatal antiepileptic drug exposure remains incomplete. Improved understanding of the neurobehavioral consequences of prenatal antiepileptic drug exposure is essential to ensure accurate information is available for women with epilepsy planning a pregnancy, and to achieve optimal outcomes for mothers and children.
Original languageEnglish
Pages (from-to)1-29
Number of pages29
JournalDevelopmental Neuropsychology
Volume37
Issue number1
Early online date31 Jan 2012
DOIs
Publication statusPublished - 2012

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Anticonvulsants
Mothers
Pregnancy
Valproic Acid
Epilepsy
Seizures
Drug Therapy
Cognitive Dysfunction

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Nadebaum, C., Anderson, V., Vajda, F., Reutens, D., & Wood, A. (2012). Neurobehavioral consequences of prenatal antiepileptic drug exposure. Developmental Neuropsychology, 37(1), 1-29. https://doi.org/10.1080/87565641.2011.589483
Nadebaum, Caroline ; Anderson, Vicki ; Vajda, Frank ; Reutens, David ; Wood, Amanda. / Neurobehavioral consequences of prenatal antiepileptic drug exposure. In: Developmental Neuropsychology. 2012 ; Vol. 37, No. 1. pp. 1-29.
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Nadebaum, C, Anderson, V, Vajda, F, Reutens, D & Wood, A 2012, 'Neurobehavioral consequences of prenatal antiepileptic drug exposure', Developmental Neuropsychology, vol. 37, no. 1, pp. 1-29. https://doi.org/10.1080/87565641.2011.589483

Neurobehavioral consequences of prenatal antiepileptic drug exposure. / Nadebaum, Caroline; Anderson, Vicki; Vajda, Frank; Reutens, David; Wood, Amanda.

In: Developmental Neuropsychology, Vol. 37, No. 1, 2012, p. 1-29.

Research output: Contribution to journalArticle

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Nadebaum C, Anderson V, Vajda F, Reutens D, Wood A. Neurobehavioral consequences of prenatal antiepileptic drug exposure. Developmental Neuropsychology. 2012;37(1):1-29. https://doi.org/10.1080/87565641.2011.589483