Neurobiology of the premonitory urge in Tourette’s syndrome: pathophysiology and treatment implications

Andrea E. Cavanna; Kevin J. Black; Mark Hallett; Valerie Voon

doi:10.1176/appi.neuropsych.16070141

Neurobiology of the premonitory urge in Tourette’s syndrome: pathophysiology and treatment implications

Andrea E. Cavanna^*
, Kevin J. Black
, Mark Hallett
, Valerie Voon

^*Corresponding author for this work

School of Psychology

University College London
Washington University in St. Louis
National Institute of Neurological Disorders and Stroke
Christie NHS Foundation Trust
Aston University

Research output: Contribution to journal › Article › peer-review

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Abstract

Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette’s syndrome (TS). Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients’ first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move (“premonitory urge”), which is transiently relieved by tic expression. This article reviews the existing literature on the clinical and neurobiological aspects of the premonitory urge in patients with TS, with focus on its pathophysiology and possible treatment implications.

Original language	English
Pages (from-to)	95-104
Number of pages	10
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	29
Issue number	2
Early online date	25 Jan 2017
DOIs	https://doi.org/10.1176/appi.neuropsych.16070141
Publication status	Published - 1 Mar 2017

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10.1176/appi.neuropsych.16070141

Neurobiology of the Premonitory Urge in Tourette’s Syndrome
Articles and other material in PMC usually include an explicit copyright statement. In the absence of a copyright statement, users should assume that standard copyright protection applies, unless the article contains an explicit statement to the contrary. In case of doubt, contact the journal publisher to verify the copyright status of an article.
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Neurobiology of the premonitory urge in Tourette’s syndrome: pathophysiology and treatment implications

Abstract

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