Neuroimaging in human amblyopia

Stephen J. Anderson*, Jennifer B. Swettenham

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and magnetoencephalography (MEG) have been the principal neuroimaging tools used to assess the site and nature of cortical deficits in human amblyopia. A review of this growing body of work is presented here with particular reference to various controversial issues, including whether or not the primary visual cortex is dysfunctional, the involvement of higher-order visual areas, neural differences between strabismic and anisometropic amblyopes, and the effects of modern-day drug treatments. We also present our own recent MEG work in which we used the analysis technique of synthetic aperture magnetometry (SAM) to examine the effects of strabismic amblyopia on cortical function. Our results provide evidence that the neuronal assembly associated with form perception in the extrastriate cortex may be dysfunctional in amblyopia, and that the nature of this dysfunction may relate to a change in the normal temporal pattern of neuronal discharges. Based on these results and existing literature, we conclude that a number of cortical areas show reduced levels of activation in amblyopia, including primary and secondary visual areas and regions within the parieto-occipital cortex and ventral temporal cortex. Copyright © 2006 Taylor & Francis Group, LLC.

Original languageEnglish
Pages (from-to)21-35
Number of pages15
JournalStrabismus
Volume14
Issue number1
DOIs
Publication statusPublished - 1 Apr 2006

Fingerprint

Amblyopia
Neuroimaging
Magnetoencephalography
Visual Cortex
Magnetometry
Form Perception
Occipital Lobe
Temporal Lobe
Positron-Emission Tomography
Magnetic Resonance Imaging
Pharmaceutical Preparations

Keywords

  • amblyopia pathogenesis
  • positron emission tomography
  • functional magnetic resonance imaging
  • magnetoencephalography
  • synthetic aperture magnetometry
  • neuroimaging
  • visual cortex

Cite this

Anderson, Stephen J. ; Swettenham, Jennifer B. / Neuroimaging in human amblyopia. In: Strabismus. 2006 ; Vol. 14, No. 1. pp. 21-35.
@article{7ad323cd09f842aab4d7625936ab5a82,
title = "Neuroimaging in human amblyopia",
abstract = "Functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and magnetoencephalography (MEG) have been the principal neuroimaging tools used to assess the site and nature of cortical deficits in human amblyopia. A review of this growing body of work is presented here with particular reference to various controversial issues, including whether or not the primary visual cortex is dysfunctional, the involvement of higher-order visual areas, neural differences between strabismic and anisometropic amblyopes, and the effects of modern-day drug treatments. We also present our own recent MEG work in which we used the analysis technique of synthetic aperture magnetometry (SAM) to examine the effects of strabismic amblyopia on cortical function. Our results provide evidence that the neuronal assembly associated with form perception in the extrastriate cortex may be dysfunctional in amblyopia, and that the nature of this dysfunction may relate to a change in the normal temporal pattern of neuronal discharges. Based on these results and existing literature, we conclude that a number of cortical areas show reduced levels of activation in amblyopia, including primary and secondary visual areas and regions within the parieto-occipital cortex and ventral temporal cortex. Copyright {\circledC} 2006 Taylor & Francis Group, LLC.",
keywords = "amblyopia pathogenesis, positron emission tomography, functional magnetic resonance imaging, magnetoencephalography, synthetic aperture magnetometry, neuroimaging, visual cortex",
author = "Anderson, {Stephen J.} and Swettenham, {Jennifer B.}",
year = "2006",
month = "4",
day = "1",
doi = "10.1080/09273970500538082",
language = "English",
volume = "14",
pages = "21--35",
journal = "Strabismus",
issn = "0927-3972",
publisher = "Informa Healthcare",
number = "1",

}

Neuroimaging in human amblyopia. / Anderson, Stephen J.; Swettenham, Jennifer B.

In: Strabismus, Vol. 14, No. 1, 01.04.2006, p. 21-35.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuroimaging in human amblyopia

AU - Anderson, Stephen J.

AU - Swettenham, Jennifer B.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and magnetoencephalography (MEG) have been the principal neuroimaging tools used to assess the site and nature of cortical deficits in human amblyopia. A review of this growing body of work is presented here with particular reference to various controversial issues, including whether or not the primary visual cortex is dysfunctional, the involvement of higher-order visual areas, neural differences between strabismic and anisometropic amblyopes, and the effects of modern-day drug treatments. We also present our own recent MEG work in which we used the analysis technique of synthetic aperture magnetometry (SAM) to examine the effects of strabismic amblyopia on cortical function. Our results provide evidence that the neuronal assembly associated with form perception in the extrastriate cortex may be dysfunctional in amblyopia, and that the nature of this dysfunction may relate to a change in the normal temporal pattern of neuronal discharges. Based on these results and existing literature, we conclude that a number of cortical areas show reduced levels of activation in amblyopia, including primary and secondary visual areas and regions within the parieto-occipital cortex and ventral temporal cortex. Copyright © 2006 Taylor & Francis Group, LLC.

AB - Functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and magnetoencephalography (MEG) have been the principal neuroimaging tools used to assess the site and nature of cortical deficits in human amblyopia. A review of this growing body of work is presented here with particular reference to various controversial issues, including whether or not the primary visual cortex is dysfunctional, the involvement of higher-order visual areas, neural differences between strabismic and anisometropic amblyopes, and the effects of modern-day drug treatments. We also present our own recent MEG work in which we used the analysis technique of synthetic aperture magnetometry (SAM) to examine the effects of strabismic amblyopia on cortical function. Our results provide evidence that the neuronal assembly associated with form perception in the extrastriate cortex may be dysfunctional in amblyopia, and that the nature of this dysfunction may relate to a change in the normal temporal pattern of neuronal discharges. Based on these results and existing literature, we conclude that a number of cortical areas show reduced levels of activation in amblyopia, including primary and secondary visual areas and regions within the parieto-occipital cortex and ventral temporal cortex. Copyright © 2006 Taylor & Francis Group, LLC.

KW - amblyopia pathogenesis

KW - positron emission tomography

KW - functional magnetic resonance imaging

KW - magnetoencephalography

KW - synthetic aperture magnetometry

KW - neuroimaging

KW - visual cortex

UR - http://www.scopus.com/inward/record.url?scp=33644774458&partnerID=8YFLogxK

U2 - 10.1080/09273970500538082

DO - 10.1080/09273970500538082

M3 - Article

C2 - 16513567

VL - 14

SP - 21

EP - 35

JO - Strabismus

JF - Strabismus

SN - 0927-3972

IS - 1

ER -