Neuroprotective effect of agmatine in mouse spinal cord injury model: Modulation by imidazoline receptors

Madhura DIxit, Manoj Upadhya, Brijesh Taksande, Prachi Raut, Milind Umekar, Nandkishor Kotagale*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The involvement of imidazoline receptors in the effect of agmatine was studied in locomotor recovery following experimental SCI (ESCI) in mice. Methods: ESCI was induced in mice using compression method. Locomotor function score (0-10) was measured on day 14 following ESCI. Results: Agmatine (2.5, 5, and 10 mg/kg) treatment through intraperitoneal route for 14 days following ESCI, dose-dependently improved the motor function score. Clonidine (0.1 mg/kg; imidazoline I1 receptor agonist) or moxonidine (0.5 mg/kg; I2 receptor agonist) treatment 15 min before agmatine (2.5 mg/kg) daily for 14 days, following ESCI, significantly potentiated the effect of per se agmatine. On the other hand, 15 min before treatment of efaroxan (1 mg/kg; imidazoline I1 receptor antagonist) or idazoxan (3 mg/kg; imidazoline I2 receptor antagonist) significantly blocked the motor function score of agmatine (10 mg/kg). Conclusion: These data suggest that imidazoline receptors may modulate the locomotor recovery following ESCI in agmatine treated mice, perhaps through I1/I2 receptors.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalJournal of Natural Science, Biology and Medicine
Volume9
Issue number2
DOIs
Publication statusPublished - 1 Jul 2018

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Keywords

  • Agmatine
  • imidazoline receptors
  • locomotor recovery
  • motor function score
  • spinal cord injury

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