Neuropsychiatric manifestations in inflammatory neuropathies: a systematic review

Yusuf A. Rajabally, Stefano Seri, Andrea E. Cavanna

Research output: Contribution to journalReview article


We conducted a systematic literature review on psychological and behavioral comorbidities in patients with inflammatory neuropathies. In Guillain-Barré syndrome (GBS), psychotic symptoms are reported during early stages in 30% of patients. Typical associations include mechanical ventilation, autonomic dysfunction, inability to communicate, and severe weakness. Anxiety and depression are frequent comorbidities. Anxiety may increase post-hospital admissions and be a predictor of mechanical ventilation. Post-traumatic stress disorder may affect up to 20% of ventilated patients. Sleep disturbances are common in early-stage GBS, affecting up to 50% of patients. In chronic inflammatory demyelinating polyradiculoneuropathy, memory and quality of sleep may be impaired. An independent link between depression and pre-treatment upper limb disability and ascites was reported in POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin) syndrome, with an association with early death. Hematological treatment of POEMS appears effective on depression. Published literature on psychological/behavioral manifestations in inflammatory neuropathies remains scarce, and further research is needed. This article is protected by copyright. All rights reserved.

Original languageEnglish
Number of pages8
JournalMuscle and Nerve
VolumeEarly view
Early online date10 May 2016
Publication statusE-pub ahead of print - 10 May 2016

Bibliographical note

This is the peer reviewed version of the following article: Rajabally, Y. A., Seri, S., & Cavanna, A. E. (2016). Neuropsychiatric manifestations in inflammatory neuropathies: a systematic review. Muscle & nerve, Early view, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.


  • chronic inflammatory demyelinating polyneuropathy
  • Guillain–Barré syndrome
  • inflammatory
  • neuropsychiatric
  • neuropathy
  • POEMS syndrome

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