TY - JOUR
T1 - Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement
AU - Ball, James D.
AU - Hills, Eleanor
AU - Altaf, Afzaa
AU - Ramesh, Pranav
AU - Green, Matthew
AU - Surti, Farhaana B.S.
AU - Minhas, Jatinder S.
AU - Robinson, Thompson G.
AU - Bond, Bert
AU - Lester, Alice
AU - Hoiland, Ryan
AU - Klein, Timo
AU - Liu, Jia
AU - Nasr, Nathalie
AU - Junejo, Rehan T.
AU - Müller, Martin
AU - Lecchini-Visintini, Andrea
AU - Mitsis, Georgios
AU - Burma, Joel S.
AU - Smirl, Jonathan D.
AU - Pizzi, Michael A.
AU - Manquat, Elsa
AU - Lucas, Samuel J. E.
AU - Mullinger, Karen J.
AU - Mayhew, Steve
AU - Bailey, Damian M.
AU - Rodrigues, Gabriel
AU - Soares, Pedro Paulo
AU - Phillips, Aaron A.
AU - Prokopiou, Prokopis C.
AU - Beishon, Lucy C.
N1 - Copyright © 2024 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
PY - 2024/12
Y1 - 2024/12
N2 - Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task activation protocols, but with significant methodological heterogeneity between studies, hindering cross-study comparisons. Therefore, this review aimed to summarise and compare available methods for TCD-based healthy NVC assessments. Medline (Ovid), Scopus, Web of Science, EMBASE (Ovid) and CINAHL were searched using a predefined search strategy (PROSPERO: CRD42019153228), generating 6006 articles. Included studies contained TCD-based assessments of NVC in healthy adults. Study quality was assessed using a checklist, and findings were synthesised narratively. 76 studies (2697 participants) met the review criteria. There was significant heterogeneity in the participant position used (e.g., seated vs supine), in TCD equipment, and vessel insonated (e.g. middle, posterior, and anterior cerebral arteries). Larger, more significant, TCD-based NVC responses typically included a seated position, baseline durations >one-minute, extraneous light control, and implementation of previously validated protocols. In addition, complementary, combined position, vessel insonated and stimulation type protocols were associated with more significant NVC results. Recommendations are detailed here, but further investigation is required in patient populations, for further optimisation of TCD-based NVC assessments.
AB - Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task activation protocols, but with significant methodological heterogeneity between studies, hindering cross-study comparisons. Therefore, this review aimed to summarise and compare available methods for TCD-based healthy NVC assessments. Medline (Ovid), Scopus, Web of Science, EMBASE (Ovid) and CINAHL were searched using a predefined search strategy (PROSPERO: CRD42019153228), generating 6006 articles. Included studies contained TCD-based assessments of NVC in healthy adults. Study quality was assessed using a checklist, and findings were synthesised narratively. 76 studies (2697 participants) met the review criteria. There was significant heterogeneity in the participant position used (e.g., seated vs supine), in TCD equipment, and vessel insonated (e.g. middle, posterior, and anterior cerebral arteries). Larger, more significant, TCD-based NVC responses typically included a seated position, baseline durations >one-minute, extraneous light control, and implementation of previously validated protocols. In addition, complementary, combined position, vessel insonated and stimulation type protocols were associated with more significant NVC results. Recommendations are detailed here, but further investigation is required in patient populations, for further optimisation of TCD-based NVC assessments.
KW - healthy
KW - narrative summary
KW - neurovascular coupling
KW - systematic review
KW - transcranial doppler ultrasonography
UR - https://journals.sagepub.com/doi/epub/10.1177/0271678X241270452
UR - http://www.scopus.com/inward/record.url?scp=85200656231&partnerID=8YFLogxK
U2 - 10.1177/0271678x241270452
DO - 10.1177/0271678x241270452
M3 - Review article
C2 - 39113406
SN - 0271-678X
VL - 44
SP - 1409
EP - 1429
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 12
ER -