New expanded bed adsorbents for the recovery of DNA

Eirini Theodosiou, Morten A Olander, Michael Søndergaard, Owen R.T. Thomas

Research output: Contribution to journalArticlepeer-review


A 20–40 μm pellicular high density (∼3.7 g cm−3) expanded bed material has been designed for the capture of DNA and other large macromolecules. Anion exchangers fashioned out of these supports exhibited dramatically enhanced DNA binding capacities over commercial anion exchange adsorbents (6 mg ml−1, c.f. ∼50 μg ml−1 at 10% breakthrough), due to a combination of small particle and ‘fuzzy’ surface architecture created through the coupling of polyethylene imine chains.
Original languageEnglish
Pages (from-to)1929-1933
JournalBiotechnology Letters
Issue number24
Publication statusPublished - 2000


  • anion exchange adsorbents
  • DNA
  • expanded bed chromatography
  • gene therapy


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