Non-invasive biomedical research and diagnostics enabled by innovative compact lasers

Karina S. Litvinova*, Ilya E. Rafailov, Andrey V. Dunaev, Sergei G. Sokolovski, Edik U. Rafailov

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

For over half a century, laser technology has undergone a technological revolution. These technologies, particularly semiconductor lasers, are employed in a myriad of fields. Optical medical diagnostics, one of the emerging areas of laser application, are on the forefront of application around the world. Optical methods of non- or minimally invasive bio-tissue investigation offer significant advantages over alternative methods, including rapid real-time measurement, non-invasiveness and high resolution (guaranteeing the safety of a patient). These advantages demonstrate the growing success of such techniques. In this review, we will outline the recent status of laser technology applied in the biomedical field, focusing on the various available approaches, particularly utilising compact semiconductor lasers. We will further consider the advancement and integration of several complimentary biophotonic techniques into single multimodal devices, the potential impact of such devices and their future applications. Based on our own studies, we will also cover the simultaneous collection of physiological data with the aid a multifunctional diagnostics system, concentrating on the optimisation of the new technology towards a clinical application. Such data is invaluable for developing algorithms capable of delivering consistent, reliable and meaningful diagnostic information, which can ultimately be employed for the early diagnosis of disease conditions in individuals from around the world.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalProgress in Quantum Electronics
Volume56
DOIs
Publication statusPublished - 12 Oct 2017

Fingerprint

Lasers
semiconductor lasers
lasers
Semiconductor lasers
laser applications
concentrating
Laser applications
emerging
safety
Time measurement
time measurement
optics
optimization
high resolution
Tissue

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/.

Funding: partially supported by grant “MESO-BRAIN” (No. 713140) of Europe Union's H2020, FET-open scheme.

Keywords

  • autofluorescence
  • compact laser
  • microcirculation
  • multifunctional laser diagnostics
  • non-invasive diagnostics
  • tissue oximetry

Cite this

@article{f0e84ee803654903bb8cf8615b15b932,
title = "Non-invasive biomedical research and diagnostics enabled by innovative compact lasers",
abstract = "For over half a century, laser technology has undergone a technological revolution. These technologies, particularly semiconductor lasers, are employed in a myriad of fields. Optical medical diagnostics, one of the emerging areas of laser application, are on the forefront of application around the world. Optical methods of non- or minimally invasive bio-tissue investigation offer significant advantages over alternative methods, including rapid real-time measurement, non-invasiveness and high resolution (guaranteeing the safety of a patient). These advantages demonstrate the growing success of such techniques. In this review, we will outline the recent status of laser technology applied in the biomedical field, focusing on the various available approaches, particularly utilising compact semiconductor lasers. We will further consider the advancement and integration of several complimentary biophotonic techniques into single multimodal devices, the potential impact of such devices and their future applications. Based on our own studies, we will also cover the simultaneous collection of physiological data with the aid a multifunctional diagnostics system, concentrating on the optimisation of the new technology towards a clinical application. Such data is invaluable for developing algorithms capable of delivering consistent, reliable and meaningful diagnostic information, which can ultimately be employed for the early diagnosis of disease conditions in individuals from around the world.",
keywords = "autofluorescence, compact laser, microcirculation, multifunctional laser diagnostics, non-invasive diagnostics, tissue oximetry",
author = "Litvinova, {Karina S.} and Rafailov, {Ilya E.} and Dunaev, {Andrey V.} and Sokolovski, {Sergei G.} and Rafailov, {Edik U.}",
note = "{\circledC} 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. Funding: partially supported by grant “MESO-BRAIN” (No. 713140) of Europe Union's H2020, FET-open scheme.",
year = "2017",
month = "10",
day = "12",
doi = "10.1016/j.pquantelec.2017.10.001",
language = "English",
volume = "56",
pages = "1--14",
journal = "Progress in Quantum Electronics",
issn = "0079-6727",
publisher = "Elsevier",

}

Non-invasive biomedical research and diagnostics enabled by innovative compact lasers. / Litvinova, Karina S.; Rafailov, Ilya E.; Dunaev, Andrey V.; Sokolovski, Sergei G.; Rafailov, Edik U.

In: Progress in Quantum Electronics, Vol. 56, 12.10.2017, p. 1-14.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Non-invasive biomedical research and diagnostics enabled by innovative compact lasers

AU - Litvinova, Karina S.

AU - Rafailov, Ilya E.

AU - Dunaev, Andrey V.

AU - Sokolovski, Sergei G.

AU - Rafailov, Edik U.

N1 - © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. Funding: partially supported by grant “MESO-BRAIN” (No. 713140) of Europe Union's H2020, FET-open scheme.

PY - 2017/10/12

Y1 - 2017/10/12

N2 - For over half a century, laser technology has undergone a technological revolution. These technologies, particularly semiconductor lasers, are employed in a myriad of fields. Optical medical diagnostics, one of the emerging areas of laser application, are on the forefront of application around the world. Optical methods of non- or minimally invasive bio-tissue investigation offer significant advantages over alternative methods, including rapid real-time measurement, non-invasiveness and high resolution (guaranteeing the safety of a patient). These advantages demonstrate the growing success of such techniques. In this review, we will outline the recent status of laser technology applied in the biomedical field, focusing on the various available approaches, particularly utilising compact semiconductor lasers. We will further consider the advancement and integration of several complimentary biophotonic techniques into single multimodal devices, the potential impact of such devices and their future applications. Based on our own studies, we will also cover the simultaneous collection of physiological data with the aid a multifunctional diagnostics system, concentrating on the optimisation of the new technology towards a clinical application. Such data is invaluable for developing algorithms capable of delivering consistent, reliable and meaningful diagnostic information, which can ultimately be employed for the early diagnosis of disease conditions in individuals from around the world.

AB - For over half a century, laser technology has undergone a technological revolution. These technologies, particularly semiconductor lasers, are employed in a myriad of fields. Optical medical diagnostics, one of the emerging areas of laser application, are on the forefront of application around the world. Optical methods of non- or minimally invasive bio-tissue investigation offer significant advantages over alternative methods, including rapid real-time measurement, non-invasiveness and high resolution (guaranteeing the safety of a patient). These advantages demonstrate the growing success of such techniques. In this review, we will outline the recent status of laser technology applied in the biomedical field, focusing on the various available approaches, particularly utilising compact semiconductor lasers. We will further consider the advancement and integration of several complimentary biophotonic techniques into single multimodal devices, the potential impact of such devices and their future applications. Based on our own studies, we will also cover the simultaneous collection of physiological data with the aid a multifunctional diagnostics system, concentrating on the optimisation of the new technology towards a clinical application. Such data is invaluable for developing algorithms capable of delivering consistent, reliable and meaningful diagnostic information, which can ultimately be employed for the early diagnosis of disease conditions in individuals from around the world.

KW - autofluorescence

KW - compact laser

KW - microcirculation

KW - multifunctional laser diagnostics

KW - non-invasive diagnostics

KW - tissue oximetry

UR - http://www.scopus.com/inward/record.url?scp=85032372757&partnerID=8YFLogxK

U2 - 10.1016/j.pquantelec.2017.10.001

DO - 10.1016/j.pquantelec.2017.10.001

M3 - Review article

AN - SCOPUS:85032372757

VL - 56

SP - 1

EP - 14

JO - Progress in Quantum Electronics

JF - Progress in Quantum Electronics

SN - 0079-6727

ER -