TY - CHAP
T1 - Non-linear dynamics in transcriptional regulation
T2 - Biological logic gates
AU - Frank, Till D.
AU - Cavadas, Miguel A.S.
AU - Nguyen, Lan K.
AU - Cheong, Alex
PY - 2016/7/21
Y1 - 2016/7/21
N2 - Gene expression relies on the interaction of numerous transcriptional signals at the promoter to elicit a response—to read or not to read the genomic code, and if read, the strength of the read. The interplay of transcription factors can be viewed as nonlinear dynamics underlying the biological complexity. Here we analyse the regulation of the cyclooxygenase 2 promoter by NF-κB using thermostatistical and quantitative kinetic modelling and propose the presence of a genetic Boolean AND logic gate controlling the differential expression of cyclooxygenase 2 among species.
AB - Gene expression relies on the interaction of numerous transcriptional signals at the promoter to elicit a response—to read or not to read the genomic code, and if read, the strength of the read. The interplay of transcription factors can be viewed as nonlinear dynamics underlying the biological complexity. Here we analyse the regulation of the cyclooxygenase 2 promoter by NF-κB using thermostatistical and quantitative kinetic modelling and propose the presence of a genetic Boolean AND logic gate controlling the differential expression of cyclooxygenase 2 among species.
UR - https://www.scopus.com/pages/publications/85046230600
UR - https://link.springer.com/chapter/10.1007%2F978-3-319-33054-9_3
U2 - 10.1007/978-3-319-33054-9_3
DO - 10.1007/978-3-319-33054-9_3
M3 - Chapter
AN - SCOPUS:85046230600
SN - 978-3-319-33053-2
T3 - SEMA SIMAI Springer Series
SP - 43
EP - 62
BT - Nonlinear Dynamics in Biological Systems
A2 - Carballido-Landeira, J
A2 - Escribano, B
PB - Springer
ER -