Noninvasive control of rhodamine-loaded capsules distribution in vivo

Olga Stelmashchuk, Y Tarakanchikova, E Seryogina, G Piavchenko, Evgeny Zherebtsov, Andrey V. Dunaev, A Popov, Igor Meglinski

Research output: Chapter in Book/Published conference outputConference publication

Abstract

Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.
Original languageEnglish
Title of host publicationProceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
PublisherSPIE
Volume10716
DOIs
Publication statusPublished - 26 Apr 2018
EventFall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX - , Russian Federation
Duration: 26 Sept 201730 Sept 2017

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume10716
ISSN (Print)0277-786X

Conference

ConferenceFall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
Country/TerritoryRussian Federation
Period26/09/1730/09/17

Bibliographical note

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