Nonlinear dynamics of cilia and flagella

Amit K. Chattopadhyay, Andreas Hilfinger, Frank Jülicher

Research output: Contribution to journalArticle

Abstract

Cilia and flagella are hairlike extensions of eukaryotic cells which generate oscillatory beat patterns that can propel micro-organisms and create fluid flows near cellular surfaces. The evolutionary highly conserved core of cilia and flagella consists of a cylindrical arrangement of nine microtubule doublets, called the axoneme. The axoneme is an actively bending structure whose motility results from the action of dynein motor proteins cross-linking microtubule doublets and generating stresses that induce bending deformations. The periodic beat patterns are the result of a mechanical feedback that leads to self-organized bending waves along the axoneme. Using a theoretical framework to describe planar beating motion, we derive a nonlinear wave equation that describes the fundamental Fourier mode of the axonemal beat. We study the role of nonlinearities and investigate how the amplitude of oscillations increases in the vicinity of an oscillatory instability. We furthermore present numerical solutions of the nonlinear wave equation for different boundary conditions. We find that the nonlinear waves are well approximated by the linearly unstable modes for amplitudes of beat patterns similar to those observed experimentally.
Original languageEnglish
Article number051918
Pages (from-to)051918
Number of pages1
JournalPhysical Review E
Volume79
Issue number5
DOIs
Publication statusPublished - 21 May 2009

Fingerprint

Beat
Nonlinear Dynamics
synchronism
Microtubules
Nonlinear Wave Equation
wave equations
Motility
locomotion
Microorganisms
Nonlinear Waves
organisms
Linking
fluid flow
Fluid Flow
Arrangement
Linearly
Unstable
nonlinearity
Numerical Solution
Nonlinearity

Bibliographical note

© 2009 The American Physical Society

Keywords

  • cilia
  • flagella
  • eukaryotic cells
  • oscillatory beat patterns
  • microtubule doublets
  • axoneme
  • dynein motor proteins
  • nonlinear wave equation
  • fundamental Fourier mode
  • amplitude of oscillations

Cite this

Chattopadhyay, Amit K. ; Hilfinger, Andreas ; Jülicher, Frank. / Nonlinear dynamics of cilia and flagella. In: Physical Review E. 2009 ; Vol. 79, No. 5. pp. 051918.
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Chattopadhyay, AK, Hilfinger, A & Jülicher, F 2009, 'Nonlinear dynamics of cilia and flagella', Physical Review E, vol. 79, no. 5, 051918, pp. 051918. https://doi.org/10.1103/PhysRevE.79.051918

Nonlinear dynamics of cilia and flagella. / Chattopadhyay, Amit K.; Hilfinger, Andreas; Jülicher, Frank.

In: Physical Review E, Vol. 79, No. 5, 051918, 21.05.2009, p. 051918.

Research output: Contribution to journalArticle

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