Normative MEG data to flash and pattern reversal stimuli

Richard A. Armstrong, A. Slaven, Paul L. Furlong, B. Janday, G.F.A. Harding

Research output: Unpublished contribution to conferenceUnpublished Conference Paperpeer-review


We have attempted to establish normative values of components of the magnetic evoked field to flash and pattern reversal stimuli prior to clinical use of the MEG. Full visual field, binocular evoked magnetic fields were recorded from 100 subjects 16 to 86 years of age with a single channel dc Squid (BTI) second-order gradiometer at a point 5-6cm above the inion. The majority of subjects showed a large positive component (out going magnetic field) of mean latency 115 ms (SD range 2.5 -11.8 in different decades of life) to the pattern reversal stimulus. In many subjects, this P100M was preceeded and succeeded by negative deflections (in going field). About 6% of subjects showed an inverted response i.e. a PNP wave. Waveforms to flash were more variable in shape with several positive components; the most consistent having a mean latency of 110ms (SD range 6.4-23.2). Responses to both stimuli were consistent when measured on the same subject on six different occasions (SD range 4.8 to 7.3). The data suggest that norms can be established for evoked magnetic field components, in particular for the pattern reversal P100M, which could be used in the diagnosis of neuro-opthalmological disease.
Original languageEnglish
Publication statusIn preparation - 1990
EventMeeting of the EEG Society - Birmingham (UK)
Duration: 21 Jun 1989 → …


ConferenceMeeting of the EEG Society
CityBirmingham (UK)
Period21/06/89 → …


  • reversal stimuli
  • MEG
  • neuro-opthalmological disease


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