Novel bioactive scaffolds incorporating nanogels as potential drug eluting devices

Virginia Sáez-Martínez, Beatriz Olalde, María J. Juan, María J. Jurado, Nerea Garagorri, Isabel Obieta

Research output: Contribution to journalArticle

Abstract

Big advances are being achieved in the design of new implantable devices with enhanced properties. For example, synthetic porous three-dimensional structures can mimic the architecture of the tissues, and serve as templates for cell seeding. In addition, polymeric nanoparticles are able to provide a programmable and sustained local delivery of different types of biomolecules. In this study novel alternative scaffolds with controlled bioactive properties and architectures are presented. Two complementary approaches are described. Firstly, scaffolds with nanogels as active controlled release devices incorporated inside the three-dimensional structure are obtained using the thermally induced phase separation (TIPS) method. Secondly, a novel coating method using the spraying technique to load these nanometric crosslinked hydrogels on the surface of two-dimensional (2D) and three-dimensional (3D) biodegradable scaffolds is described. The scanning electron microscopy (SEM) images show the distribution of the nanogels on the surface of different substrates and also inside the porous structure of poly-a-hydroxy ester derivative foams. Both of them are compared in terms of manufacturability, dispersion and other processing variables.
Original languageEnglish
Pages (from-to)2826-2832
Number of pages7
JournalJournal of Nanoscience and Nanotechnology
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • scaffolds
  • nanoparticles
  • nanogels
  • controlled release
  • tips
  • spray-coating

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    Sáez-Martínez, V., Olalde, B., Juan, M. J., Jurado, M. J., Garagorri, N., & Obieta, I. (2010). Novel bioactive scaffolds incorporating nanogels as potential drug eluting devices. Journal of Nanoscience and Nanotechnology, 10(4), 2826-2832. https://doi.org/10.1166/jnn.2010.1448