Novel drug targets for asthma and COPD: Lessons learned from invitro and invivo models

Katie E. Baker; Sara J. Bonvini; Chantal Donovan; Rachel E. Foong; Bing Han; Aruni Jha; Yasin Shaifta; Marieke Smit; Jill R. Johnson; Lyn M. Moir

doi:10.1016/j.pupt.2014.05.008

Novel drug targets for asthma and COPD: Lessons learned from invitro and invivo models

Katie E. Baker
, Sara J. Bonvini
, Chantal Donovan
, Rachel E. Foong
, Bing Han
, Aruni Jha
, Yasin Shaifta
, Marieke Smit
, Jill R. Johnson
, Lyn M. Moir^*

^*Corresponding author for this work

National Heart and Lung Institute
University of Melbourne
Telethon Kids Institute
Rijksuniversiteit Groningen
University of Groningen, University Medical Center Groningen
University of Manitoba
King's College London
Woolcock Institute of Medical Research
University of Sydney

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent respiratory diseases characterized by airway inflammation, airway obstruction and airway hyperresponsiveness. Whilst current therapies, such as β-agonists and glucocorticoids, may be effective at reducing symptoms, they do not reduce disease progression. Thus, there is a need to identify new therapeutic targets. In this review, we summarize the potential of novel targets or tools, including anti-inflammatories, phosphodiesterase inhibitors, kinase inhibitors, transient receptor potential channels, vitamin D and protease inhibitors, for the treatment of asthma and COPD.

Original language	English
Pages (from-to)	181-198
Number of pages	18
Journal	Pulmonary Pharmacology and Therapeutics
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.pupt.2014.05.008
Publication status	Published - Dec 2014

Funding

K.E.B. is supported by the Medical Research Council (MRC), UK. S.J.B. is supported by the National Heart & Lung Institute , UK. C.D. is supported by an Australian Postgraduate Award . R.E.F has received funding from the Australian Postgraduate Award and Stan and Jean Perron PhD Top-Up Scholarship . Y.S. is supported by the Wellcome Trust . J.R.J. is supported by an Imperial College London Junior Research Fellowship and an MRC New Investigator Award . L.M.M. was supported by the National Health and Medical Research Council , Australia and the LAM Australasia Research Alliance (LARA), Australia.

Keywords

G-protein coupled receptor
Inflammation
Kinase
Therapeutic targets
Transient receptor potential channel
Vitamin D

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10.1016/j.pupt.2014.05.008

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title = "Novel drug targets for asthma and COPD: Lessons learned from invitro and invivo models",

abstract = "Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent respiratory diseases characterized by airway inflammation, airway obstruction and airway hyperresponsiveness. Whilst current therapies, such as β-agonists and glucocorticoids, may be effective at reducing symptoms, they do not reduce disease progression. Thus, there is a need to identify new therapeutic targets. In this review, we summarize the potential of novel targets or tools, including anti-inflammatories, phosphodiesterase inhibitors, kinase inhibitors, transient receptor potential channels, vitamin D and protease inhibitors, for the treatment of asthma and COPD.",

keywords = "G-protein coupled receptor, Inflammation, Kinase, Therapeutic targets, Transient receptor potential channel, Vitamin D",

author = "Baker, \{Katie E.\} and Bonvini, \{Sara J.\} and Chantal Donovan and Foong, \{Rachel E.\} and Bing Han and Aruni Jha and Yasin Shaifta and Marieke Smit and Johnson, \{Jill R.\} and Moir, \{Lyn M.\}",

year = "2014",

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doi = "10.1016/j.pupt.2014.05.008",

language = "English",

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AU - Baker, Katie E.

AU - Bonvini, Sara J.

AU - Donovan, Chantal

AU - Foong, Rachel E.

AU - Han, Bing

AU - Jha, Aruni

AU - Shaifta, Yasin

AU - Smit, Marieke

AU - Johnson, Jill R.

AU - Moir, Lyn M.

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AB - Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent respiratory diseases characterized by airway inflammation, airway obstruction and airway hyperresponsiveness. Whilst current therapies, such as β-agonists and glucocorticoids, may be effective at reducing symptoms, they do not reduce disease progression. Thus, there is a need to identify new therapeutic targets. In this review, we summarize the potential of novel targets or tools, including anti-inflammatories, phosphodiesterase inhibitors, kinase inhibitors, transient receptor potential channels, vitamin D and protease inhibitors, for the treatment of asthma and COPD.

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KW - Inflammation

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KW - Therapeutic targets

KW - Transient receptor potential channel

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Novel drug targets for asthma and COPD: Lessons learned from invitro and invivo models

Abstract

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Keywords

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