Novel synthesis of biodegradable star poly(ethylene glycol)-block- poly(lactide) copolymers

Yahia Lemmouchi, Michael C. Perry, Allant J. Amass*, Khirud Chakraborty, Etienne Schacht

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Biodegradable star-shaped poly(ethylene glycol)-block-poly(lactide) copolymers were synthesized by ring-opening polymerization of lactide, using star polyethylene glycol) as an initiator and potassium hexamethyldisilazide as a catalyst. Polymerizations were carried out in toluene at room temperature. Two series of threeand four-armed PEG-PLA copolymers were synthesized and characterized by gel permeation chromatography (GPC) as well as 1H and 13C NMR spectroscopy. The polymerization under the used conditions is very fast, yielding copolymers of controlled molecular weight and tailored molecular architecture. The chemical structure of the copolymers investigated by 1H and 13C NMR indicates the formation of block copolymers. The monomodal profile of molecular weight distribution by GPC provided further evidence of controlled and defined star-shaped copolymers as well as the absence of cyclic oligomeric species. The effects of copolymer composition and lactide stereochemistry on the physical properties were investigated by GPC and differential scanning calorimetry. For the same PLA chain length, the materials obtained in the case of linear copolymers are more viscous, whereas in the case of star copolymer, solid materials are obtained with reduction in their T g and T m temperatures.

Original languageEnglish
Pages (from-to)3966-3974
Number of pages9
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume45
Issue number17
DOIs
Publication statusPublished - 17 Jul 2007

Fingerprint

Polyethylene glycols
Stars
Copolymers
Gel permeation chromatography
Polymerization
Stereochemistry
poly(lactide)
Ring opening polymerization
Toluene
Molecular weight distribution
Chain length
Nuclear magnetic resonance spectroscopy
Block copolymers
Potassium
Differential scanning calorimetry
Physical properties
Molecular weight
Nuclear magnetic resonance
Temperature
Catalysts

Keywords

  • Biodegradable
  • Poly(ethylene glycol)
  • Poly(lactide)
  • Polyesters
  • Ring-opening polymerization
  • Star copolymers

Cite this

Lemmouchi, Yahia ; Perry, Michael C. ; Amass, Allant J. ; Chakraborty, Khirud ; Schacht, Etienne. / Novel synthesis of biodegradable star poly(ethylene glycol)-block- poly(lactide) copolymers. In: Journal of Polymer Science, Part A: Polymer Chemistry. 2007 ; Vol. 45, No. 17. pp. 3966-3974.
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abstract = "Biodegradable star-shaped poly(ethylene glycol)-block-poly(lactide) copolymers were synthesized by ring-opening polymerization of lactide, using star polyethylene glycol) as an initiator and potassium hexamethyldisilazide as a catalyst. Polymerizations were carried out in toluene at room temperature. Two series of threeand four-armed PEG-PLA copolymers were synthesized and characterized by gel permeation chromatography (GPC) as well as 1H and 13C NMR spectroscopy. The polymerization under the used conditions is very fast, yielding copolymers of controlled molecular weight and tailored molecular architecture. The chemical structure of the copolymers investigated by 1H and 13C NMR indicates the formation of block copolymers. The monomodal profile of molecular weight distribution by GPC provided further evidence of controlled and defined star-shaped copolymers as well as the absence of cyclic oligomeric species. The effects of copolymer composition and lactide stereochemistry on the physical properties were investigated by GPC and differential scanning calorimetry. For the same PLA chain length, the materials obtained in the case of linear copolymers are more viscous, whereas in the case of star copolymer, solid materials are obtained with reduction in their T g and T m temperatures.",
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Novel synthesis of biodegradable star poly(ethylene glycol)-block- poly(lactide) copolymers. / Lemmouchi, Yahia; Perry, Michael C.; Amass, Allant J.; Chakraborty, Khirud; Schacht, Etienne.

In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 45, No. 17, 17.07.2007, p. 3966-3974.

Research output: Contribution to journalArticle

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T1 - Novel synthesis of biodegradable star poly(ethylene glycol)-block- poly(lactide) copolymers

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AU - Perry, Michael C.

AU - Amass, Allant J.

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AU - Schacht, Etienne

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