Numerical Simulation of Stent Angioplasty with Predilation: An Investigation into Lesion Constitutive Representation and Calcification Influence

C. Conway, J. P. McGarry, E. R. Edelman, P. E. McHugh

Research output: Contribution to journalArticle

Abstract

It is acceptable clinical practice to predilate a severely occluded vessel to allow better positioning of endovascular stents, and while the impact of this intervention has been examined for aggregate response in animals there has been no means to examine whether there are specific vessels that might benefit. Finite element methods offer the singular ability to explore the mechanical response of arteries with specific pathologic alterations in mechanics to stenting and predilation. We examined varying representations of atherosclerotic tissue including homogeneous and heterogeneous dispersion of calcified particles, and elastic, pseudo-elastic, and elastic–plastic constitutive representations of bulk atherosclerotic tissue. The constitutive representations of the bulk atherosclerotic tissue were derived from experimental test data and highlight the importance of accounting for testing mode of loading. The impact of arterial predilation is presented and, in particular, its effect on intimal predicted damage, atherosclerotic tissue von Mises and maximum principal stresses, and luminal deformation was dependent on the type of constitutive representation of diseased tissue, particularly in the presence of calcifications.
Original languageEnglish
Pages (from-to)2244–2252
JournalAnnals of Biomedical Engineering
Volume45
Issue number9
Early online date9 May 2017
DOIs
Publication statusPublished - 9 Sep 2017

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Stents
Tissue
Computer simulation
Mechanics
Animals
Finite element method
Testing

Bibliographical note

© Springer Nature B.V. 2017. The final publication is available at Springer via http://dx.doi.org/10.1007/s10439-017-1851-3

Cite this

Conway, C. ; McGarry, J. P. ; Edelman, E. R. ; McHugh, P. E. / Numerical Simulation of Stent Angioplasty with Predilation: An Investigation into Lesion Constitutive Representation and Calcification Influence. In: Annals of Biomedical Engineering. 2017 ; Vol. 45, No. 9. pp. 2244–2252.
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Numerical Simulation of Stent Angioplasty with Predilation: An Investigation into Lesion Constitutive Representation and Calcification Influence. / Conway, C.; McGarry, J. P.; Edelman, E. R.; McHugh, P. E.

In: Annals of Biomedical Engineering, Vol. 45, No. 9, 09.09.2017, p. 2244–2252.

Research output: Contribution to journalArticle

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