Obstructive sleep apnea and retinopathy in patients with type 2 diabetes: a longitudinal study

Quratul A. Altaf, Paul Dodson, Asad Ali, Neil T. Raymond, Helen Wharton, Hannah Fellows, Rachel Hampshire-Bancroft, Mirriam Shah, Emma Shepherd, Jamili Miah, Anthony H. Barnett, Abd A. Tahrani

Research output: Contribution to journalArticle

Abstract

Rationale: Obstructive sleep apnea (OSA) is associated with several pathophysiological deficits found in diabetic retinopathy (DR). Hence, it’s plausible that OSA could play a role in the pathogenesis of sight-threatening DR (STDR). Objectives: To assess the relationship between OSA and DR in patients with type 2 diabetes and to assess whether OSA is associated with its progression. Methods: A longitudinal study was conducted in diabetes clinics within two U.K. hospitals. Patients known to have any respiratory disorder (including OSA) were excluded. DR was assessed using two field 45-degree retinal images for each eye. OSA was assessed using home-based multichannel cardiorespiratory device. Measurements and Main Results: A total of 230 patients were included. STDR and OSA prevalence rates were 36.1% and 63.9%, respectively. STDR prevalence was higher in patients with OSA than in those without OSA (42.9% vs. 24.1%; P = 0.004). After adjustment for confounders, OSA remained independently associated with STDR (odds ratio, 2.3; 95% confidence interval, 1.1–4.9; P = 0.04). After a median (interquartile range) follow-up of 43.0 (37.0–51.0) months, patients with OSA were more likely than patients without OSA to develop preproliferative/proliferative DR (18.4% vs. 6.1%; P = 0.02). After adjustment for confounders, OSA remained an independent predictor of progression to preproliferative/proliferative DR (odds ratio, 5.2; 95% CI confidence interval, 1.2–23.0; P = 0.03). Patients who received continuous positive airway pressure treatment were significantly less likely to develop preproliferative/proliferative DR. Conclusions: OSA is associated with STDR in patients with type 2 diabetes. OSA is an independent predictor for the progression to preproliferative/proliferative DR. Continuous positive airway pressure treatment was associated with reduction in preproliferative/proliferative DR. Interventional studies are needed to assess the impact of OSA treatment on STDR.

Original languageEnglish
Pages (from-to)892-900
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume196
Issue number7
Early online date1 Oct 2017
DOIs
Publication statusE-pub ahead of print - 1 Oct 2017

Bibliographical note

Copyright © 2017 American Thoracic Society.

Funding: National Institute for Health Research via a research training fellowship (RTF/01/094) and clinician scientist award (CS-2013-13-029) (A.A.T.).

Keywords

  • diabetic retinopathy
  • maculopathy
  • obstructive sleep apnea

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    Altaf, Q. A., Dodson, P., Ali, A., Raymond, N. T., Wharton, H., Fellows, H., Hampshire-Bancroft, R., Shah, M., Shepherd, E., Miah, J., Barnett, A. H., & Tahrani, A. A. (2017). Obstructive sleep apnea and retinopathy in patients with type 2 diabetes: a longitudinal study. American Journal of Respiratory and Critical Care Medicine, 196(7), 892-900. https://doi.org/10.1164/rccm.201701-0175OC