Ocular and systemic endothelial function in the off spring of diabetics: a pilot study

Sunni Patel; Doina Gherghel; Rebekka Heitmar; A. Benavente-Perez; Lu Qin; David McIntyre; G.M. Balanos; Jonathan Gibson

doi:10.1111/j.1755-3768.2009.454.x

Abstract

Purpose To investigate ocular and systemic correlates of endothelial function in the normoglycaemic offspring of Type 2 Diabetics (T2DM).
Methods Healthy participants aged between 25-65 with (n=30) and without (n=39) a family history were recruited. Retinal vessel reactivity was assessed by using the Retinal Vessel Analyser (RVA, Imedos GmBH). In addition, systemic endothelial function was assessed by using the flow mediated dilation (FMD) technique.
Results Parametric testing showed no significant differences in anthropometric, blood assay or ocular and systemic function between both groups (p>0.05). The average maximum dilation in the measured retinal artery correlated significantly with the maximum dilation of the measured brachial artery (p=0.002 R=0.55) in healthy controls; however, this was not true for subjects with family history of T2DM.
Conclusion Subjects with family history of T2DM show possibly early signs of endothelial dysfunction that, in certain conditions, could contribute to the higher risk of this group of developing similar pathology to their parents.

Original language	English
DOIs	https://doi.org/10.1111/j.1755-3768.2009.454.x
Publication status	Published - Sept 2009
Event	EVER - PORTOROZ, Slovenia Duration: 30 Sept 2009 → 3 Oct 2009

Conference

Conference	EVER
Country/Territory	Slovenia
City	PORTOROZ
Period	30/09/09 → 3/10/09

Bibliographical note

Abstract published in Acta Ophthalmologica, Special Issue: Abstracts from the 2009 European Association for Vision and Eye Research Conference, Volume 87, Issue Supplement s244, September 2009.

Access to Document

10.1111/j.1755-3768.2009.454.x

Cite this

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title = "Ocular and systemic endothelial function in the off spring of diabetics: a pilot study",

abstract = "Purpose To investigate ocular and systemic correlates of endothelial function in the normoglycaemic offspring of Type 2 Diabetics (T2DM).Methods Healthy participants aged between 25-65 with (n=30) and without (n=39) a family history were recruited. Retinal vessel reactivity was assessed by using the Retinal Vessel Analyser (RVA, Imedos GmBH). In addition, systemic endothelial function was assessed by using the flow mediated dilation (FMD) technique.Results Parametric testing showed no significant differences in anthropometric, blood assay or ocular and systemic function between both groups (p>0.05). The average maximum dilation in the measured retinal artery correlated significantly with the maximum dilation of the measured brachial artery (p=0.002 R=0.55) in healthy controls; however, this was not true for subjects with family history of T2DM.Conclusion Subjects with family history of T2DM show possibly early signs of endothelial dysfunction that, in certain conditions, could contribute to the higher risk of this group of developing similar pathology to their parents.",

author = "Sunni Patel and Doina Gherghel and Rebekka Heitmar and A. Benavente-Perez and Lu Qin and David McIntyre and G.M. Balanos and Jonathan Gibson",

note = "Abstract published in Acta Ophthalmologica, Special Issue: Abstracts from the 2009 European Association for Vision and Eye Research Conference, Volume 87, Issue Supplement s244, September 2009. ; EVER ; Conference date: 30-09-2009 Through 03-10-2009",

year = "2009",

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doi = "10.1111/j.1755-3768.2009.454.x",

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TY - CONF

T1 - Ocular and systemic endothelial function in the off spring of diabetics

T2 - EVER

AU - Patel, Sunni

AU - Gherghel, Doina

AU - Heitmar, Rebekka

AU - Benavente-Perez, A.

AU - Qin, Lu

AU - McIntyre, David

AU - Balanos, G.M.

AU - Gibson, Jonathan

N1 - Abstract published in Acta Ophthalmologica, Special Issue: Abstracts from the 2009 European Association for Vision and Eye Research Conference, Volume 87, Issue Supplement s244, September 2009.

PY - 2009/9

Y1 - 2009/9

N2 - Purpose To investigate ocular and systemic correlates of endothelial function in the normoglycaemic offspring of Type 2 Diabetics (T2DM).Methods Healthy participants aged between 25-65 with (n=30) and without (n=39) a family history were recruited. Retinal vessel reactivity was assessed by using the Retinal Vessel Analyser (RVA, Imedos GmBH). In addition, systemic endothelial function was assessed by using the flow mediated dilation (FMD) technique.Results Parametric testing showed no significant differences in anthropometric, blood assay or ocular and systemic function between both groups (p>0.05). The average maximum dilation in the measured retinal artery correlated significantly with the maximum dilation of the measured brachial artery (p=0.002 R=0.55) in healthy controls; however, this was not true for subjects with family history of T2DM.Conclusion Subjects with family history of T2DM show possibly early signs of endothelial dysfunction that, in certain conditions, could contribute to the higher risk of this group of developing similar pathology to their parents.

AB - Purpose To investigate ocular and systemic correlates of endothelial function in the normoglycaemic offspring of Type 2 Diabetics (T2DM).Methods Healthy participants aged between 25-65 with (n=30) and without (n=39) a family history were recruited. Retinal vessel reactivity was assessed by using the Retinal Vessel Analyser (RVA, Imedos GmBH). In addition, systemic endothelial function was assessed by using the flow mediated dilation (FMD) technique.Results Parametric testing showed no significant differences in anthropometric, blood assay or ocular and systemic function between both groups (p>0.05). The average maximum dilation in the measured retinal artery correlated significantly with the maximum dilation of the measured brachial artery (p=0.002 R=0.55) in healthy controls; however, this was not true for subjects with family history of T2DM.Conclusion Subjects with family history of T2DM show possibly early signs of endothelial dysfunction that, in certain conditions, could contribute to the higher risk of this group of developing similar pathology to their parents.

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U2 - 10.1111/j.1755-3768.2009.454.x

DO - 10.1111/j.1755-3768.2009.454.x

M3 - Abstract

Y2 - 30 September 2009 through 3 October 2009

ER -