On the neural basis of word reading: A meta-analysis of fMRI evidence using activation likelihood estimation

Kelly Murphy*, Joel B Talcott, Jigar R Jogia

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The neural networks that support normal single word reading have been studied extensively with functional magnetic resonance imaging (fMRI) and been heavily meta analysed; yet two caveats persist. Firstly, inclusion criteria are generally broad, allowing for a range of studies with inconsistent methodological practices to become a major source of variance in the data. Secondly, the sophistication of meta analytic techniques are ever improving, calling for a continuation of quantitative summaries for more informed interpretations of the literature. We conducted a novel meta-analysis using the updated activation likelihood estimation (ALE) approach on fMRI data from 345 native English speakers published from 1992 to 2014, comparing neural correlates between single word reading (SWR); and lexical decision tasks (LDT). SWR paradigms activated a highly predictable, left lateralised reading network, whereas LDT, did not; and instead, fewer clusters overall were found in bilateral regions associated with orthographic, semantic and decision making processes, as well as traces of eye and hand movements. A conjunction analysis conducted on shared LDT/SWR activations found left fusiform and right inferior frontal gyral (IFG) regions to be common to both tasks; but an overlapping right inferior, precentral and middle frontal cluster to be specific to LDT. The findings from this meta analysis warn of the implications of having broad inclusion criteria when meta analysing heavily researched phenomena. We demonstrate the importance of the considerations researchers need to make when designing their paradigms as task related activations in single word reading can heavily influence our interpretation of the nature of the reading network.

Original languageEnglish
Pages (from-to)71-83
Number of pages13
JournalJournal of Neurolinguistics
Volume49
Early online date15 Sep 2018
DOIs
Publication statusPublished - 1 Feb 2019

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activation
Meta-Analysis
Reading
Magnetic Resonance Imaging
evidence
inclusion
paradigm
interpretation
decision making process
Eye Movements
Meta-analysis
Word Reading
Functional Magnetic Resonance Imaging
Activation
Semantics
neural network
Decision Making
Lexical Decision Task
Hand
semantics

Bibliographical note

© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Cite this

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abstract = "The neural networks that support normal single word reading have been studied extensively with functional magnetic resonance imaging (fMRI) and been heavily meta analysed; yet two caveats persist. Firstly, inclusion criteria are generally broad, allowing for a range of studies with inconsistent methodological practices to become a major source of variance in the data. Secondly, the sophistication of meta analytic techniques are ever improving, calling for a continuation of quantitative summaries for more informed interpretations of the literature. We conducted a novel meta-analysis using the updated activation likelihood estimation (ALE) approach on fMRI data from 345 native English speakers published from 1992 to 2014, comparing neural correlates between single word reading (SWR); and lexical decision tasks (LDT). SWR paradigms activated a highly predictable, left lateralised reading network, whereas LDT, did not; and instead, fewer clusters overall were found in bilateral regions associated with orthographic, semantic and decision making processes, as well as traces of eye and hand movements. A conjunction analysis conducted on shared LDT/SWR activations found left fusiform and right inferior frontal gyral (IFG) regions to be common to both tasks; but an overlapping right inferior, precentral and middle frontal cluster to be specific to LDT. The findings from this meta analysis warn of the implications of having broad inclusion criteria when meta analysing heavily researched phenomena. We demonstrate the importance of the considerations researchers need to make when designing their paradigms as task related activations in single word reading can heavily influence our interpretation of the nature of the reading network.",
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On the neural basis of word reading : A meta-analysis of fMRI evidence using activation likelihood estimation. / Murphy, Kelly; Talcott, Joel B; Jogia, Jigar R.

In: Journal of Neurolinguistics, Vol. 49, 01.02.2019, p. 71-83.

Research output: Contribution to journalArticle

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