One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility

Yifan Jia, Weiwen Yuan, Mengmeng Xu, Congyi Yang, Lei Chen, Shuo Wang, Paul D. Topham, Guoxuan Luo, Mo Wang, Yong Zhang*, Guihua Jiang, Qianqian Yu, Lin Ge Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Magnetic resonance imaging (MRI)-active polymers exhibit unique advantages for in vivo diagnosis. Here, in order to endow electrospun fibers with long-term T1 positive MRI visibility, MRI contrast agent (CA), Gd(OH)3, is introduced in a new, extremely convenient method. Crucially, GdCl3 is reacted with NaOH in situ during electrospinning, with flexibility to deliver both well-dispersed and aggregated Gd(OH)3 clusters within a poly(ethylene terephthalate) (PET) matrix. T1 and T2 relaxivities of Gd(OH)3 in PET nanofibers are studied. Well-dispersed Gd(OH)3 (sub-nanometer in size) exhibits 34 times higher T1 relaxivity than aggregated nanoparticles when embedded within the fibers. The morphology, structure, magnetic properties, tensile properties, imaging performance and biosafety of the PET/Gd(OH)3 composite fibers are evaluated to identify the optimum conditions to produce new materials with balanced properties, excellent in vivo positive contrast and approximately 139 days imaging lifetime. Comparing this sample with a commercial CA, only 0.32 wt.% Gd loading is needed to attain similar MRI signal intensity. In summary, PET/Gd(OH)3 long-term MRI-active fibers show great potential for future biomedical applications and the study also provides a promising new general strategy to enhance the MRI T1 positive contrast of electrospun fibers of a whole host of other systems.

Original languageEnglish
Article number100121
JournalGiant
Volume12
Early online date18 Oct 2022
DOIs
Publication statusPublished - Dec 2022

Bibliographical note

© 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Funding Information:
The authors thank the financial support from the National Key R&D Program of China (No. 2017YFC1105003), Guangdong Project (No. 2016ZT06C322), Overseas Expertise Introduction Center for Discipline Innovation (“111 Center”), Science and Technology Program of Guangzhou (No. 202102020759), and Science Foundation of Guangdong Second Provincial General Hospital (No. 3D-B2020010).

Keywords

  • Electrospinning
  • Gadolinium
  • Long-term visibility
  • Magnetic nanofibers
  • Magnetic resonance imaging
  • T positive contrast

Fingerprint

Dive into the research topics of 'One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility'. Together they form a unique fingerprint.

Cite this