The paper presents the results of in vivo experimental measurements of the endogenous fluorescence and blood perfusion in common bile duct tissues in obstructive jaundice patients during minimally invasive surgical operations. Nowadays the type of interventions become more widespread for treating hepatopancreatobiliary pathologies. An effective feedback which can be established by one or more optical diagnostic channels integrated into the standard instruments for minimally invasive manipulations would be of particular value to practical surgeons. To collect reference data, an experimental study has been conducted using a fiber optical probe with fluorescence spectroscopy and laser Doppler flowmetry channels. For every measurement, the areas of interest were different areas of common bile duct obstructed by a malignant tumor. Obtained results demonstrated significant variety registered intensities of fluorescence spectra and values of blood perfusion. Tested fiber optical endoscopic system showed sensitivity to the tissue state in the investigated area, so the two modal approach seems to be promising for further research and implementation in clinical practice.
|Journal||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Publication status||Published - 3 Jun 2019|
|Event||Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, SFM 2018 - Saratov, Russian Federation|
Duration: 24 Sep 2018 → 28 Sep 2018
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- Common bile duct
- Fluorescence spectroscopy
- Laser Doppler flowmetry
- Minimally invasive surgery
- Obstructive jaundice
- Optical biopsy
- Optical diagnostics
- Tumor compression