Optical fine-needle biopsy approach for intraoperative multimodal diagnostics in minimally invasive abdominal surgery

Ksenia Kandurova*, Elena Potapova, Valery Shupletsov, Igor Kozlov, Evgeniya Seryogina, Viktor Dremin, Evgeny Zherebtsov, Alexander Alekseyev, Andrian Mamoshin, Andrey Dunaev

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


The paper describes the methodology and technical implementation of a multimodal approach for optical diagnostics in hepatopancreatobiliary organs focal and diffuse neoplasms. Fine needle aspiration biopsy technique and following cytological examination show its effectiveness and safety but its performing takes several days. However, the problem of real-time analysis of pathological changes in tissues remains relevant. The solution suggested is implementing of optical biopsy methods (namely fluorescence spectroscopy and diffuse reflectance spectroscopy) in the form of fiber-optic probe compatible with standard biopsy fine needles. The special device was designed for this purpose to conduct optical measurements and compare the results with ones obtained by conventional biopsy. The proposed methodology seems promising for developing new diagnostic criteria for clinical practice.

Original languageEnglish
Article number110791C
JournalOptics InfoBase Conference Papers
Publication statusPublished - 22 Jul 2019
EventEuropean Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands
Duration: 23 Jun 201925 Jun 2019

Bibliographical note

Copyright 2019 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.


  • Diffuse reflectance spectroscopy
  • Fine-needle aspiration biopsy
  • Fluorescence spectroscopy
  • Minimally invasive surgery
  • Optical biopsy
  • Tumor


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