TY - JOUR
T1 - Optical probe pressure effects on cutaneous blood flow
AU - Mizeva, Irina A.
AU - Potapova, Elena V.
AU - Dremin, Viktor V.
AU - Zherebtsov, Evgeny A.
AU - Mezentsev, Mikhail A.
AU - Shuleptsov, Valery V.
AU - Dunaev, Andrey V.
N1 - Publisher Copyright:
© 2019 - IOS Press and the authors. All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/9/11
Y1 - 2019/9/11
N2 - The variation of blood flow characteristics caused by the probe pressure during noninvasive studies is of particular interest within the context of fundamental and applied research. It has been shown previously that the weak local pressure induces vasodilation, whereas the increased pressure is able to stop the blood flow in the compressed area, as well as to significantly change optical signals. The blood flow oscillations measured by laser Doppler flowmetry (LDF) characterize the functional state of the microvascular system and can be used for noninvasive diagnostics of its abnormality. This study was intended to identify the patterns of the relationship between the oscillating components of blood flow registered by the LDF method under different levels of pressure applied to an optical fiber probe. For this purpose, we have developed an original optical probe capable of regulating the applied pressure. The developed protocol included six sequential records of the blood perfusion at a pressure within the 0 to 200mmHg range with unloading at the last stage. Using wavelet analyses, we traced the variation of energy of oscillations for these records in five frequency bands associated with different vascular tone regulation mechanisms. Six young volunteers of the same age (three males and three females) were included in this preliminary study and the protocol was repeated five times in each volunteer. Accordingly, 30 LDF records were available for the analyses. As expected, the LDF signal increases at weak pressure (30mmHg) and decreases at increased pressure. The statistically stable amplification of endothelial associated blood flow oscillations under the 90mmHg pressure allowed us to put forward a hypothesis that the endothelial activity increases. The possible causes of this phenomenon are discussed.
AB - The variation of blood flow characteristics caused by the probe pressure during noninvasive studies is of particular interest within the context of fundamental and applied research. It has been shown previously that the weak local pressure induces vasodilation, whereas the increased pressure is able to stop the blood flow in the compressed area, as well as to significantly change optical signals. The blood flow oscillations measured by laser Doppler flowmetry (LDF) characterize the functional state of the microvascular system and can be used for noninvasive diagnostics of its abnormality. This study was intended to identify the patterns of the relationship between the oscillating components of blood flow registered by the LDF method under different levels of pressure applied to an optical fiber probe. For this purpose, we have developed an original optical probe capable of regulating the applied pressure. The developed protocol included six sequential records of the blood perfusion at a pressure within the 0 to 200mmHg range with unloading at the last stage. Using wavelet analyses, we traced the variation of energy of oscillations for these records in five frequency bands associated with different vascular tone regulation mechanisms. Six young volunteers of the same age (three males and three females) were included in this preliminary study and the protocol was repeated five times in each volunteer. Accordingly, 30 LDF records were available for the analyses. As expected, the LDF signal increases at weak pressure (30mmHg) and decreases at increased pressure. The statistically stable amplification of endothelial associated blood flow oscillations under the 90mmHg pressure allowed us to put forward a hypothesis that the endothelial activity increases. The possible causes of this phenomenon are discussed.
UR - http://www.scopus.com/inward/record.url?scp=85072234784&partnerID=8YFLogxK
UR - https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180459
U2 - 10.3233/CH-180459
DO - 10.3233/CH-180459
M3 - Article
C2 - 30958335
AN - SCOPUS:85072234784
VL - 72
SP - 259
EP - 267
JO - Clinical Hemorheology and Microcirculation
JF - Clinical Hemorheology and Microcirculation
SN - 1386-0291
IS - 3
ER -