Optical strategy utilising contrast modulation to slow myopia

James S. Wolffsohn, Kate L. Gifford

Research output: Contribution to journalArticlepeer-review

Abstract

A new method to slow myopia progression utilises Diffusion Optics Technology™ (DOT) spectacle lenses. The proposed mechanism of action for the DOT lenses is to modulate contrast across the photoreceptor cells, leading to an altered activity of the ON and OFF pathways and slowing the progression of axial elongation. This approach is different to the current optical approaches that utilise optical defocus to reduce hyperopic defocus at the peripheral retina while central vision is fully corrected to slow myopia. Initial clinical studies with the DOT lenses have demonstrated promising results with a reduction in progression of myopia. This overview summarises the current knowledge on myopia risk factors, the evidence for involvement of contrast signalling pathways in refractive error development, and the theories and mechanisms behind DOT lens technology. It also considers the role for contrast and the paradoxical observations given the established paradigm of form deprivation in animal models.
Original languageEnglish
JournalOphthalmology Science
Early online date9 Dec 2024
DOIs
Publication statusE-pub ahead of print - 9 Dec 2024

Bibliographical note

Copyright © 2024, Elsevier. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/. The Version of Record will be found at: https://doi.org/10.1016/j.xops.2024.100672

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