Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

Yi Hu, Zhen-Chu Chen, Zhang-Gao Le, Qinguo Zheng

Research output: Contribution to journalArticlepeer-review

Abstract

Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

Original languageEnglish
Pages (from-to)3801-3806
Number of pages6
JournalSynthetic communications
Volume34
Issue number20
DOIs
Publication statusPublished - 12 Nov 2004

Keywords

  • 2-Aminothiophene
  • Gewald reaction
  • ionic liquids
  • knoevenagel condensation

Fingerprint Dive into the research topics of 'Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate'. Together they form a unique fingerprint.

Cite this