Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

Yi Hu; Zhen-Chu Chen; Zhang-Gao Le; Qinguo Zheng

doi:10.1081/SCC-200032526

Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

Yi Hu, Zhen-Chu Chen, Zhang-Gao Le, Qinguo Zheng

Research output: Contribution to journal › Article › peer-review

Abstract

Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF₄) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF₆) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

Original language	English
Pages (from-to)	3801-3806
Number of pages	6
Journal	Synthetic communications
Volume	34
Issue number	20
DOIs	https://doi.org/10.1081/SCC-200032526
Publication status	Published - 12 Nov 2004

Keywords

2-Aminothiophene
Gewald reaction
ionic liquids
knoevenagel condensation

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10.1081/SCC-200032526

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title = "Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate",

abstract = "Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.",

keywords = "2-Aminothiophene, Gewald reaction, ionic liquids, knoevenagel condensation",

author = "Yi Hu and Zhen-Chu Chen and Zhang-Gao Le and Qinguo Zheng",

year = "2004",

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doi = "10.1081/SCC-200032526",

language = "English",

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journal = "Synthetic communications",

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T1 - Organic reactions in ionic liquids

T2 - Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

AU - Hu, Yi

AU - Chen, Zhen-Chu

AU - Le, Zhang-Gao

AU - Zheng, Qinguo

PY - 2004/11/12

Y1 - 2004/11/12

N2 - Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

AB - Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

KW - 2-Aminothiophene

KW - Gewald reaction

KW - ionic liquids

KW - knoevenagel condensation

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UR - https://www.tandfonline.com/doi/abs/10.1081/SCC-200032526

U2 - 10.1081/SCC-200032526

DO - 10.1081/SCC-200032526

M3 - Article

SN - 0039-7911

VL - 34

SP - 3801

EP - 3806

JO - Synthetic communications

JF - Synthetic communications

IS - 20

ER -

Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

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