Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

Edith M. Allen, John B. Matthews, Domhnall J. O'Halloran, Helen R Griffiths, Iain L. Chapple

Research output: Contribution to journalArticle

Abstract

Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.

Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.

Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower ß-cell function (HOMA-ß; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.

Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.
LanguageEnglish
Pages894-901
Number of pages8
JournalJournal of Clinical Periodontology
Volume38
Issue number10
Early online date24 Aug 2011
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Periodontitis
Type 2 Diabetes Mellitus
Fasting
Body Mass Index
C-Reactive Protein
Oxidative Stress
Antioxidants
Lipids
Glucose
Fibrinogen
HDL Cholesterol
Insulin Resistance
Proteins
Leukocytes

Keywords

  • adult
  • aged
  • B-lymphocytes
  • blood glucose
  • body mass index
  • c-reactive protein
  • case-control studies
  • HDL cholesterol
  • chronic periodontitis
  • type 2 diabetes mellitus
  • female
  • glycosylated hemoglobin A
  • humans
  • insulin resistance
  • male
  • middle aged
  • oxidative stress
  • protein carbonylation
  • diabetes
  • inflammation
  • periodontitis

Cite this

Allen, E. M., Matthews, J. B., O'Halloran, D. J., Griffiths, H. R., & Chapple, I. L. (2011). Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. Journal of Clinical Periodontology, 38(10), 894-901. https://doi.org/10.1111/j.1600-051X.2011.01764.x
Allen, Edith M. ; Matthews, John B. ; O'Halloran, Domhnall J. ; Griffiths, Helen R ; Chapple, Iain L. / Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. In: Journal of Clinical Periodontology. 2011 ; Vol. 38, No. 10. pp. 894-901.
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Allen, EM, Matthews, JB, O'Halloran, DJ, Griffiths, HR & Chapple, IL 2011, 'Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis' Journal of Clinical Periodontology, vol. 38, no. 10, pp. 894-901. https://doi.org/10.1111/j.1600-051X.2011.01764.x

Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. / Allen, Edith M.; Matthews, John B.; O'Halloran, Domhnall J.; Griffiths, Helen R; Chapple, Iain L.

In: Journal of Clinical Periodontology, Vol. 38, No. 10, 10.2011, p. 894-901.

Research output: Contribution to journalArticle

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AU - Matthews, John B.

AU - O'Halloran, Domhnall J.

AU - Griffiths, Helen R

AU - Chapple, Iain L.

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N2 - Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower ß-cell function (HOMA-ß; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.

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