Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

Edith M. Allen; John B. Matthews; Domhnall J. O'Halloran; Helen R Griffiths; Iain L. Chapple

doi:10.1111/j.1600-051X.2011.01764.x

Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

Edith M. Allen
, John B. Matthews
, Domhnall J. O'Halloran
, Helen R Griffiths
, Iain L. Chapple

Cork University Hospital
University College Birmingham

Research output: Contribution to journal › Article › peer-review

108 Citations (SciVal)

Abstract

Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.

Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.

Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower ß-cell function (HOMA-ß; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.

Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.

Original language	English
Pages (from-to)	894-901
Number of pages	8
Journal	Journal of Clinical Periodontology
Volume	38
Issue number	10
Early online date	24 Aug 2011
DOIs	https://doi.org/10.1111/j.1600-051X.2011.01764.x
Publication status	Published - Oct 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adult
aged
B-lymphocytes
blood glucose
body mass index
c-reactive protein
case-control studies
HDL cholesterol
chronic periodontitis
type 2 diabetes mellitus
female
glycosylated hemoglobin A
humans
insulin resistance
male
middle aged
oxidative stress
protein carbonylation
diabetes
inflammation
periodontitis

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10.1111/j.1600-051X.2011.01764.x

Cite this

@article{050c264ad6b14a0fab1f11e0e54aae3b,

title = "Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis",

abstract = "Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes. Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS. Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower {\ss}-cell function (HOMA-{\ss}; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups. Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.",

keywords = "adult, aged, B-lymphocytes, blood glucose, body mass index, c-reactive protein, case-control studies, HDL cholesterol, chronic periodontitis, type 2 diabetes mellitus, female, glycosylated hemoglobin A, humans, insulin resistance, male, middle aged, oxidative stress, protein carbonylation, diabetes, inflammation, periodontitis",

author = "Allen, \{Edith M.\} and Matthews, \{John B.\} and O'Halloran, \{Domhnall J.\} and Griffiths, \{Helen R\} and Chapple, \{Iain L.\}",

note = "{\textcopyright} 2011 John Wiley \& Sons A/S.",

year = "2011",

month = oct,

doi = "10.1111/j.1600-051X.2011.01764.x",

language = "English",

volume = "38",

pages = "894--901",

journal = "Journal of Clinical Periodontology",

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TY - JOUR

T1 - Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

AU - Allen, Edith M.

AU - Matthews, John B.

AU - O'Halloran, Domhnall J.

AU - Griffiths, Helen R

AU - Chapple, Iain L.

PY - 2011/10

Y1 - 2011/10

N2 - Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes. Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS. Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower ß-cell function (HOMA-ß; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups. Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.

AB - Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes. Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS. Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower ß-cell function (HOMA-ß; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups. Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.

KW - adult

KW - aged

KW - B-lymphocytes

KW - blood glucose

KW - body mass index

KW - c-reactive protein

KW - case-control studies

KW - HDL cholesterol

KW - chronic periodontitis

KW - type 2 diabetes mellitus

KW - female

KW - glycosylated hemoglobin A

KW - humans

KW - insulin resistance

KW - male

KW - middle aged

KW - oxidative stress

KW - protein carbonylation

KW - diabetes

KW - inflammation

KW - periodontitis

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UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2011.01764.x/abstract

U2 - 10.1111/j.1600-051X.2011.01764.x

DO - 10.1111/j.1600-051X.2011.01764.x

M3 - Article

C2 - 21883360

SN - 1600-051X

VL - 38

SP - 894

EP - 901

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

IS - 10

ER -

Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

Abstract

UN SDGs

Keywords

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