Oxidized phospholipids: their properties and interactions with proteins

Albin Hermetter, Paavo Kinnunen, Corinne Spickett

Research output: Contribution to journalEditorial

Abstract

Lipids are a highly diverse class of biomolecules, with an average eukaryotic cell estimated as containing at least 100,000 different species. The significance of this diversity is still poorly understood, yet it has become clear that lipids have critical regulatory as well as structural roles, varying from signaling (e.g. phosphatidylinositols, prostaglandins, platelet activating factor, ceramide) to the control of permeability properties of skin, for instance.

An unprecedented discovery from recent efforts in lipidomics, aimed at the elucidation of the functional roles of lipids in cells, was the key role for lipid oxidation in cell behavior and pathology. More specifically, oxidized phospholipids (oxPL) have been shown to increase significantly in apoptosis as well as in inflammation and to be involved in several pathological conditions, such as atherosclerosis, cancer, inflammation, Alzheimer's and Parkinson's disease, as well as type 2 diabetes, with the detailed mechanisms remaining to be established. However, a coherent overall view of the causalities and mechanisms has been lacking, mainly because of insufficient understanding of the cellular as well as molecular level mechanisms. This Special Issue represents a focused, integrated interdisciplinary approach summarizing very recent leading edge developments in this emerging field with emphasis on lipid–protein interactions. The data now becoming available are paving the way to the development of improved diagnostics, therapies and preventive measures to combat the above diseases.
LanguageEnglish
Pages2373
Number of pages1
JournalBBA -Biomembranes
Volume1818
Issue number10
DOIs
Publication statusPublished - 1 Oct 2012

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Phospholipids
Lipids
Proteins
Inflammation
Ceramides
Platelet Activating Factor
Biomolecules
Eukaryotic Cells
Pathology
Medical problems
Phosphatidylinositols
Causality
Type 2 Diabetes Mellitus
Prostaglandins
Parkinson Disease
Permeability
Atherosclerosis
Skin
Alzheimer Disease
Apoptosis

Cite this

Hermetter, Albin ; Kinnunen, Paavo ; Spickett, Corinne. / Oxidized phospholipids : their properties and interactions with proteins. In: BBA -Biomembranes. 2012 ; Vol. 1818, No. 10. pp. 2373.
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Oxidized phospholipids : their properties and interactions with proteins. / Hermetter, Albin; Kinnunen, Paavo; Spickett, Corinne.

In: BBA -Biomembranes, Vol. 1818, No. 10, 01.10.2012, p. 2373.

Research output: Contribution to journalEditorial

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