Oxygen tension, H2S, and NO bioavailability: is there an interaction?

Gopi K. Kolluru, Priya K. Prasai, Amir M. Kaskas, Vijay Letchuman, Christopher B. Pattillo

Research output: Contribution to journalArticlepeer-review


Molecular oxygen (O2) is an essential component for survival and development. Variation in O2 levels leads to changes in molecular signaling and ultimately affects the physiological functions of many organisms. Nitric oxide (NO) and hydrogen sulfide (H2S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H2S are believed to mediate hypoxic responses and serve as O2 chemosensors in biological systems. In this literature review, we briefly discuss NO and H2S and their roles during hypoxia.

Original languageEnglish
Pages (from-to)263-270
Number of pages8
Journal Journal of Applied Physiology
Issue number2
Early online date17 Sept 2015
Publication statusPublished - 15 Jan 2016


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