Parkinsonian features in a case of pellagra: a historical report

Andrea E. Cavanna*, A. Nani, A.C. Williams

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Pellagra is a complex systemic disease resulting from inadequate dietary intake of coenzyme precursors nicotinamide and tryptophan. Improved nutritional habits in most developed economies have led to a decrease in clinicians' and researchers' attention to this condition and its pathophysiological bases, although new cases of pellagra have recently been identified in association with alcohol abuse and HIV infection in Western countries. Pellagra is characterized by a complex clinical picture, which can include neuropsychiatric symptoms and Parkinsonian features. Interestingly, pellagra and Parkinson's disease could share some basic pathophysiological mechanisms at the level of nicotinamide metabolism, resulting in mitochondrial dysfunction and alterations in dopaminergic pathways. Both neuropsychiatric and motor symptoms were mentioned in historical reports of pellagra cohorts. Here we present the English translation of the first detailed description of an original case of pellagra with Parkinsonian features, documented in a clinical note by Dr Giuseppe Paravicini one century ago.

Original languageEnglish
Pages (from-to)539-545
Number of pages7
JournalJournal of Parkinson's Disease
Volume3
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Pellagra
Niacinamide
Coenzymes
Tryptophan
Alcoholism
Habits
HIV Infections
Parkinson Disease
Research Personnel

Keywords

  • historical description
  • motor signs
  • parkinson's disease
  • pellagra

Cite this

Cavanna, Andrea E. ; Nani, A. ; Williams, A.C. / Parkinsonian features in a case of pellagra : a historical report. In: Journal of Parkinson's Disease. 2013 ; Vol. 3, No. 4. pp. 539-545.
@article{92fe2b01c187478f9434ac2219360a2c,
title = "Parkinsonian features in a case of pellagra: a historical report",
abstract = "Pellagra is a complex systemic disease resulting from inadequate dietary intake of coenzyme precursors nicotinamide and tryptophan. Improved nutritional habits in most developed economies have led to a decrease in clinicians' and researchers' attention to this condition and its pathophysiological bases, although new cases of pellagra have recently been identified in association with alcohol abuse and HIV infection in Western countries. Pellagra is characterized by a complex clinical picture, which can include neuropsychiatric symptoms and Parkinsonian features. Interestingly, pellagra and Parkinson's disease could share some basic pathophysiological mechanisms at the level of nicotinamide metabolism, resulting in mitochondrial dysfunction and alterations in dopaminergic pathways. Both neuropsychiatric and motor symptoms were mentioned in historical reports of pellagra cohorts. Here we present the English translation of the first detailed description of an original case of pellagra with Parkinsonian features, documented in a clinical note by Dr Giuseppe Paravicini one century ago.",
keywords = "historical description, motor signs, parkinson's disease, pellagra",
author = "Cavanna, {Andrea E.} and A. Nani and A.C. Williams",
year = "2013",
doi = "10.3233/JPD-130242",
language = "English",
volume = "3",
pages = "539--545",
journal = "Journal of Parkinson's Disease",
issn = "1877-7171",
publisher = "IOS",
number = "4",

}

Parkinsonian features in a case of pellagra : a historical report. / Cavanna, Andrea E.; Nani, A.; Williams, A.C.

In: Journal of Parkinson's Disease, Vol. 3, No. 4, 2013, p. 539-545.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Parkinsonian features in a case of pellagra

T2 - a historical report

AU - Cavanna, Andrea E.

AU - Nani, A.

AU - Williams, A.C.

PY - 2013

Y1 - 2013

N2 - Pellagra is a complex systemic disease resulting from inadequate dietary intake of coenzyme precursors nicotinamide and tryptophan. Improved nutritional habits in most developed economies have led to a decrease in clinicians' and researchers' attention to this condition and its pathophysiological bases, although new cases of pellagra have recently been identified in association with alcohol abuse and HIV infection in Western countries. Pellagra is characterized by a complex clinical picture, which can include neuropsychiatric symptoms and Parkinsonian features. Interestingly, pellagra and Parkinson's disease could share some basic pathophysiological mechanisms at the level of nicotinamide metabolism, resulting in mitochondrial dysfunction and alterations in dopaminergic pathways. Both neuropsychiatric and motor symptoms were mentioned in historical reports of pellagra cohorts. Here we present the English translation of the first detailed description of an original case of pellagra with Parkinsonian features, documented in a clinical note by Dr Giuseppe Paravicini one century ago.

AB - Pellagra is a complex systemic disease resulting from inadequate dietary intake of coenzyme precursors nicotinamide and tryptophan. Improved nutritional habits in most developed economies have led to a decrease in clinicians' and researchers' attention to this condition and its pathophysiological bases, although new cases of pellagra have recently been identified in association with alcohol abuse and HIV infection in Western countries. Pellagra is characterized by a complex clinical picture, which can include neuropsychiatric symptoms and Parkinsonian features. Interestingly, pellagra and Parkinson's disease could share some basic pathophysiological mechanisms at the level of nicotinamide metabolism, resulting in mitochondrial dysfunction and alterations in dopaminergic pathways. Both neuropsychiatric and motor symptoms were mentioned in historical reports of pellagra cohorts. Here we present the English translation of the first detailed description of an original case of pellagra with Parkinsonian features, documented in a clinical note by Dr Giuseppe Paravicini one century ago.

KW - historical description

KW - motor signs

KW - parkinson's disease

KW - pellagra

UR - http://www.scopus.com/inward/record.url?scp=84898729959&partnerID=8YFLogxK

U2 - 10.3233/JPD-130242

DO - 10.3233/JPD-130242

M3 - Article

C2 - 24028927

AN - SCOPUS:84898729959

VL - 3

SP - 539

EP - 545

JO - Journal of Parkinson's Disease

JF - Journal of Parkinson's Disease

SN - 1877-7171

IS - 4

ER -