Pathways mediating functional recovery

Stuart N. Baker*, Boubker Zaaimi, Karen M. Fisher, Steve A. Edgley, Demetris S. Soteropoulos

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Following damage to the motor system (e.g., after stroke or spinal cord injury), recovery of upper limb function exploits the multiple pathways which allow motor commands to be sent to the spinal cord. Corticospinal fibers originate from premotor as well as primary motor cortex. While some corticospinal fibers make direct monosynaptic connections to motoneurons, there are also many connections to interneurons which allow control of motoneurons indirectly. Such interneurons may be placed within the cervical enlargement, or more rostrally (propriospinal interneurons). In addition, connections from cortex to the reticular formation in the brainstem allow motor commands to be sent over the reticulospinal tract to these spinal centers. In this review, we consider the relative roles of these different routes for the control of hand function, both in healthy primates and after recovery from lesion.

Original languageEnglish
Title of host publicationProgress in Brain Research
Pages389-412
Number of pages24
DOIs
Publication statusPublished - 1 Jan 2015

Publication series

NameProgress in Brain Research
Volume218
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Fingerprint

Interneurons
Motor Neurons
Reticular Formation
Motor Cortex
Spinal Cord Injuries
Upper Extremity
Primates
Brain Stem
Spinal Cord
Hand
Stroke

Bibliographical note

Imprint: Elsevier.

Keywords

  • Corticospinal
  • Hand
  • Motor cortex
  • Primate
  • Propriospinal
  • Pyramidal tract
  • Reticulospinal

Cite this

Baker, S. N., Zaaimi, B., Fisher, K. M., Edgley, S. A., & Soteropoulos, D. S. (2015). Pathways mediating functional recovery. In Progress in Brain Research (pp. 389-412). (Progress in Brain Research; Vol. 218). https://doi.org/10.1016/bs.pbr.2014.12.010
Baker, Stuart N. ; Zaaimi, Boubker ; Fisher, Karen M. ; Edgley, Steve A. ; Soteropoulos, Demetris S. / Pathways mediating functional recovery. Progress in Brain Research. 2015. pp. 389-412 (Progress in Brain Research).
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Baker, SN, Zaaimi, B, Fisher, KM, Edgley, SA & Soteropoulos, DS 2015, Pathways mediating functional recovery. in Progress in Brain Research. Progress in Brain Research, vol. 218, pp. 389-412. https://doi.org/10.1016/bs.pbr.2014.12.010

Pathways mediating functional recovery. / Baker, Stuart N.; Zaaimi, Boubker; Fisher, Karen M.; Edgley, Steve A.; Soteropoulos, Demetris S.

Progress in Brain Research. 2015. p. 389-412 (Progress in Brain Research; Vol. 218).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Baker SN, Zaaimi B, Fisher KM, Edgley SA, Soteropoulos DS. Pathways mediating functional recovery. In Progress in Brain Research. 2015. p. 389-412. (Progress in Brain Research). https://doi.org/10.1016/bs.pbr.2014.12.010