Abstract
Following damage to the motor system (e.g., after stroke or spinal cord injury), recovery of upper limb function exploits the multiple pathways which allow motor commands to be sent to the spinal cord. Corticospinal fibers originate from premotor as well as primary motor cortex. While some corticospinal fibers make direct monosynaptic connections to motoneurons, there are also many connections to interneurons which allow control of motoneurons indirectly. Such interneurons may be placed within the cervical enlargement, or more rostrally (propriospinal interneurons). In addition, connections from cortex to the reticular formation in the brainstem allow motor commands to be sent over the reticulospinal tract to these spinal centers. In this review, we consider the relative roles of these different routes for the control of hand function, both in healthy primates and after recovery from lesion.
| Original language | English |
|---|---|
| Title of host publication | Progress in Brain Research |
| Pages | 389-412 |
| Number of pages | 24 |
| DOIs | |
| Publication status | Published - 1 Jan 2015 |
Publication series
| Name | Progress in Brain Research |
|---|---|
| Volume | 218 |
| ISSN (Print) | 0079-6123 |
| ISSN (Electronic) | 1875-7855 |
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Bibliographical note
Imprint: Elsevier.Keywords
- Corticospinal
- Hand
- Motor cortex
- Primate
- Propriospinal
- Pyramidal tract
- Reticulospinal
Cite this
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Pathways mediating functional recovery. / Baker, Stuart N.; Zaaimi, Boubker; Fisher, Karen M.; Edgley, Steve A.; Soteropoulos, Demetris S.
Progress in Brain Research. 2015. p. 389-412 (Progress in Brain Research; Vol. 218).Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Pathways mediating functional recovery
AU - Baker, Stuart N.
AU - Zaaimi, Boubker
AU - Fisher, Karen M.
AU - Edgley, Steve A.
AU - Soteropoulos, Demetris S.
N1 - Imprint: Elsevier.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Following damage to the motor system (e.g., after stroke or spinal cord injury), recovery of upper limb function exploits the multiple pathways which allow motor commands to be sent to the spinal cord. Corticospinal fibers originate from premotor as well as primary motor cortex. While some corticospinal fibers make direct monosynaptic connections to motoneurons, there are also many connections to interneurons which allow control of motoneurons indirectly. Such interneurons may be placed within the cervical enlargement, or more rostrally (propriospinal interneurons). In addition, connections from cortex to the reticular formation in the brainstem allow motor commands to be sent over the reticulospinal tract to these spinal centers. In this review, we consider the relative roles of these different routes for the control of hand function, both in healthy primates and after recovery from lesion.
AB - Following damage to the motor system (e.g., after stroke or spinal cord injury), recovery of upper limb function exploits the multiple pathways which allow motor commands to be sent to the spinal cord. Corticospinal fibers originate from premotor as well as primary motor cortex. While some corticospinal fibers make direct monosynaptic connections to motoneurons, there are also many connections to interneurons which allow control of motoneurons indirectly. Such interneurons may be placed within the cervical enlargement, or more rostrally (propriospinal interneurons). In addition, connections from cortex to the reticular formation in the brainstem allow motor commands to be sent over the reticulospinal tract to these spinal centers. In this review, we consider the relative roles of these different routes for the control of hand function, both in healthy primates and after recovery from lesion.
KW - Corticospinal
KW - Hand
KW - Motor cortex
KW - Primate
KW - Propriospinal
KW - Pyramidal tract
KW - Reticulospinal
UR - http://www.scopus.com/inward/record.url?scp=84955422075&partnerID=8YFLogxK
UR - https://www.elsevier.com/books/sensorimotor-rehabilitation/dancause/978-0-444-63565-5
U2 - 10.1016/bs.pbr.2014.12.010
DO - 10.1016/bs.pbr.2014.12.010
M3 - Chapter
C2 - 25890147
AN - SCOPUS:84955422075
T3 - Progress in Brain Research
SP - 389
EP - 412
BT - Progress in Brain Research
ER -