Patient-reported outcome measures for asthma: a systematic review

Allison Worth, Victoria Hammersley, Rebecca Knibb, Bertine Flokstra-de-Blok, Audrey DunnGalvin, Samantha Walker, Anthony E.J. Dubois, Aziz Sheikh

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Patient-reported outcome measures (PROMs) are measures of the outcome of treatment(s) reported directly by the patient or carer. There is increasing international policy interest in using these to assess the impact of clinical care. AIMS: To identify suitably validated PROMs for asthma and examine their potential for use in clinical settings. METHODS: We systematically searched MEDLINE, EMBASE and Web of Science databases from 1990 onwards to identify PROMs for asthma. These were critically appraised, then narratively synthesised. We also identified the generic PROMs commonly used alongside asthma-specific PROMs. RESULTS: We identifi ed 68 PROMs for asthma, 13 of which were selected through screening as being adequately developed to warrant full-quality appraisal: 8 for adults, 4 for children and 1 for a child's caregiver. The PROMs found to be sufficiently well validated to offer promise for use in clinical settings were the Asthma Quality of Life Questionnaire (AQLQ) and mini-AQLQ for adults, and Pediatric Asthma Quality of Life Questionnaire for children. Rhinasthma was considered promising in simultaneously assessing the impact of asthma and rhinitis in those with coexistent disease. We identified 28 generic PROMs commonly used in conjunction with asthma-specific instruments. CONCLUSIONS: We identified asthma PROMs that offer the greatest potential for use in clinical settings. Further work is needed to assess whether these are fit-for-purpose for use in clinical practice with individual patients. In particular, there is a need to ensure these are validated for use in clinical settings, acceptable to patients, caregivers and clinicians, and yield meaningful outcomes. © 2014 Primary Care Respiratory Society/Macmillan Publishers Limited.

LanguageEnglish
Article number14020
Pages14020
Number of pages8
JournalNPJ Primary Care Respiratory Medicine
Volume24
DOIs
Publication statusPublished - 26 Jun 2014

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Asthma
Caregivers
Quality of Life
Patient Reported Outcome Measures
Rhinitis
MEDLINE
Primary Health Care
Outcome Assessment (Health Care)
Databases
Pediatrics
Surveys and Questionnaires

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if thematerial is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

Cite this

Worth, A., Hammersley, V., Knibb, R., Flokstra-de-Blok, B., DunnGalvin, A., Walker, S., ... Sheikh, A. (2014). Patient-reported outcome measures for asthma: a systematic review. NPJ Primary Care Respiratory Medicine, 24, 14020. [14020]. https://doi.org/10.1038/npjpcrm.2014.20
Worth, Allison ; Hammersley, Victoria ; Knibb, Rebecca ; Flokstra-de-Blok, Bertine ; DunnGalvin, Audrey ; Walker, Samantha ; Dubois, Anthony E.J. ; Sheikh, Aziz. / Patient-reported outcome measures for asthma : a systematic review. In: NPJ Primary Care Respiratory Medicine. 2014 ; Vol. 24. pp. 14020.
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Worth, A, Hammersley, V, Knibb, R, Flokstra-de-Blok, B, DunnGalvin, A, Walker, S, Dubois, AEJ & Sheikh, A 2014, 'Patient-reported outcome measures for asthma: a systematic review' NPJ Primary Care Respiratory Medicine, vol. 24, 14020, pp. 14020. https://doi.org/10.1038/npjpcrm.2014.20

Patient-reported outcome measures for asthma : a systematic review. / Worth, Allison; Hammersley, Victoria; Knibb, Rebecca; Flokstra-de-Blok, Bertine; DunnGalvin, Audrey; Walker, Samantha; Dubois, Anthony E.J.; Sheikh, Aziz.

In: NPJ Primary Care Respiratory Medicine, Vol. 24, 14020, 26.06.2014, p. 14020.

Research output: Contribution to journalArticle

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AU - Sheikh, Aziz

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Y1 - 2014/6/26

N2 - BACKGROUND: Patient-reported outcome measures (PROMs) are measures of the outcome of treatment(s) reported directly by the patient or carer. There is increasing international policy interest in using these to assess the impact of clinical care. AIMS: To identify suitably validated PROMs for asthma and examine their potential for use in clinical settings. METHODS: We systematically searched MEDLINE, EMBASE and Web of Science databases from 1990 onwards to identify PROMs for asthma. These were critically appraised, then narratively synthesised. We also identified the generic PROMs commonly used alongside asthma-specific PROMs. RESULTS: We identifi ed 68 PROMs for asthma, 13 of which were selected through screening as being adequately developed to warrant full-quality appraisal: 8 for adults, 4 for children and 1 for a child's caregiver. The PROMs found to be sufficiently well validated to offer promise for use in clinical settings were the Asthma Quality of Life Questionnaire (AQLQ) and mini-AQLQ for adults, and Pediatric Asthma Quality of Life Questionnaire for children. Rhinasthma was considered promising in simultaneously assessing the impact of asthma and rhinitis in those with coexistent disease. We identified 28 generic PROMs commonly used in conjunction with asthma-specific instruments. CONCLUSIONS: We identified asthma PROMs that offer the greatest potential for use in clinical settings. Further work is needed to assess whether these are fit-for-purpose for use in clinical practice with individual patients. In particular, there is a need to ensure these are validated for use in clinical settings, acceptable to patients, caregivers and clinicians, and yield meaningful outcomes. © 2014 Primary Care Respiratory Society/Macmillan Publishers Limited.

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Worth A, Hammersley V, Knibb R, Flokstra-de-Blok B, DunnGalvin A, Walker S et al. Patient-reported outcome measures for asthma: a systematic review. NPJ Primary Care Respiratory Medicine. 2014 Jun 26;24:14020. 14020. https://doi.org/10.1038/npjpcrm.2014.20