Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism

P. Edwards, R.J. Cattell, J.A. Blair, Richard A. Armstrong

Research output: Contribution to conferencePaper

Abstract

The P2 visual evoked response in man has a cholinergic component while the P100 response has not. The P100 latency is significantly decreased after an oral dose of phenylalanine in man while the P2 signal is unaffected. Analyses of the P100 decrease shows no correlation with tyrosine levels but a significant positive correlation with plasma ane urine levels. A small group shows a P100 delay which correlated with increased neopterin levels only. Increased plasma total biopterins in man following a phenylalanine dose are due to rapidly increased tetrahydrobiopterin synthesis in the liver.
Original languageEnglish
Publication statusUnpublished - 1993
Event12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines - St. Christoph, Arlberg, Austria
Duration: 1 Feb 1993 → …

Workshop

Workshop12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines
CountryAustria
CitySt. Christoph, Arlberg
Period1/02/93 → …

Fingerprint

Visual Evoked Potentials
Phenylalanine
Biopterin
Neopterin
Cholinergic Agents
Tyrosine
Urine
Liver
sapropterin

Bibliographical note

Abstract appearing in Pteridines 4:P96-97, 0933-4807.

Keywords

  • visual evoked response
  • P100
  • P2
  • plasma total biopterins
  • tetrahydrobiopterin synthesis
  • liver

Cite this

Edwards, P., Cattell, R. J., Blair, J. A., & Armstrong, R. A. (1993). Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.
Edwards, P. ; Cattell, R.J. ; Blair, J.A. ; Armstrong, Richard A. / Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.
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abstract = "The P2 visual evoked response in man has a cholinergic component while the P100 response has not. The P100 latency is significantly decreased after an oral dose of phenylalanine in man while the P2 signal is unaffected. Analyses of the P100 decrease shows no correlation with tyrosine levels but a significant positive correlation with plasma ane urine levels. A small group shows a P100 delay which correlated with increased neopterin levels only. Increased plasma total biopterins in man following a phenylalanine dose are due to rapidly increased tetrahydrobiopterin synthesis in the liver.",
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Edwards, P, Cattell, RJ, Blair, JA & Armstrong, RA 1993, 'Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism' Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria, 1/02/93, .

Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism. / Edwards, P.; Cattell, R.J.; Blair, J.A.; Armstrong, Richard A.

1993. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism

AU - Edwards, P.

AU - Cattell, R.J.

AU - Blair, J.A.

AU - Armstrong, Richard A.

N1 - Abstract appearing in Pteridines 4:P96-97, 0933-4807.

PY - 1993

Y1 - 1993

N2 - The P2 visual evoked response in man has a cholinergic component while the P100 response has not. The P100 latency is significantly decreased after an oral dose of phenylalanine in man while the P2 signal is unaffected. Analyses of the P100 decrease shows no correlation with tyrosine levels but a significant positive correlation with plasma ane urine levels. A small group shows a P100 delay which correlated with increased neopterin levels only. Increased plasma total biopterins in man following a phenylalanine dose are due to rapidly increased tetrahydrobiopterin synthesis in the liver.

AB - The P2 visual evoked response in man has a cholinergic component while the P100 response has not. The P100 latency is significantly decreased after an oral dose of phenylalanine in man while the P2 signal is unaffected. Analyses of the P100 decrease shows no correlation with tyrosine levels but a significant positive correlation with plasma ane urine levels. A small group shows a P100 delay which correlated with increased neopterin levels only. Increased plasma total biopterins in man following a phenylalanine dose are due to rapidly increased tetrahydrobiopterin synthesis in the liver.

KW - visual evoked response

KW - P100

KW - P2

KW - plasma total biopterins

KW - tetrahydrobiopterin synthesis

KW - liver

M3 - Paper

ER -

Edwards P, Cattell RJ, Blair JA, Armstrong RA. Pattern visual evoked potentials in man and tetrahydrobiopterin metabolism. 1993. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.