Pericytes in Chronic Lung Disease

Bushra Shammout, Jill R. Johnson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pericytes are supportive mesenchymal cells located on the abluminal surface of the microvasculature, with key roles in regulating microvascular homeostasis, leukocyte extravasation, and angiogenesis. A subpopulation of pericytes with progenitor cell function has recently been identified, with evidence demonstrating the capacity of tissue-resident pericytes to differentiate into the classic MSC triad, i.e., osteocytes, chondrocytes, and adipocytes. Beyond the regenerative capacity of these cells, studies have shown that pericytes play crucial roles in various pathologies in the lung, both acute (acute respiratory distress syndrome and sepsis-related pulmonary edema) and chronic (pulmonary hypertension, lung tumors, idiopathic pulmonary fibrosis, asthma, and chronic obstructive pulmonary disease). Taken together, this body of evidence suggests that, in the presence of acute and chronic pulmonary inflammation, pericytes are not associated with tissue regeneration and repair, but rather transform into scar-forming myofibroblasts, with devastating outcomes regarding lung structure and function. It is hoped that further studies into the mechanisms of pericyte-to-myofibroblast transition and migration to fibrotic foci will clarify the roles of pericytes in chronic lung disease and open up new avenues in the search for novel treatments for human pulmonary pathologies.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Chapter14
Pages299-317
Number of pages19
ISBN (Electronic)978-3-030-16908-4
ISBN (Print)978-3-030-16907-7
DOIs
Publication statusPublished - 31 May 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1147
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Acute respiratory distress syndrome
  • Asthma
  • Chronic obstructive pulmonary disease
  • Edema
  • Fibrosis
  • Idiopathic pulmonary hypertension
  • Lung
  • Migration
  • Myofibroblast
  • Pericyte
  • Pulmonary hypertension
  • Tumor
  • Vasculature

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  • Cite this

    Shammout, B., & Johnson, J. R. (2019). Pericytes in Chronic Lung Disease. In Advances in Experimental Medicine and Biology (pp. 299-317). (Advances in Experimental Medicine and Biology; Vol. 1147). Springer. https://doi.org/10.1007/978-3-030-16908-4_14