meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing
neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm)
of lymphatic drainage and clearance. Our results obtained at optical coherence tomography
(OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of
the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of
lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported
by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume
that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying
increasing the permeability of the lymphatic endothelium that allows molecules transported by
the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These
findings open new strategies for the stimulation of MLVs functions and non-pharmacological
therapy of brain diseases.
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Funding: Russian Science Foundation (17-15-01263, 18-15-00172, 19-15-00201).