Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions

Oxana Semyachkina-glushkovskaya, Arkady Abdurashitov, Alexander Dubrovsky, Maria Klimova, Ilana Agranovich, Andrey Terskov, Alexander Shirokov, Valeria Vinnik, Anna Kuznecova, Nikita Lezhnev, Inna Blokhina, Anastassia Shnitenkova, Valery Tuchin, Edik Rafailov, Jurgen Kurths

Research output: Contribution to journalArticle

Abstract

There is a hypothesis that augmentation of the drainage and clearing function of the
meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing
neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm)
of lymphatic drainage and clearance. Our results obtained at optical coherence tomography
(OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of
the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of
lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported
by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume
that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying
increasing the permeability of the lymphatic endothelium that allows molecules transported by
the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These
findings open new strategies for the stimulation of MLVs functions and non-pharmacological
therapy of brain diseases.
Original languageEnglish
Pages (from-to)725-734
Number of pages10
JournalBiomedical Optics Express
Volume11
Issue number2
Early online date10 Jan 2020
DOIs
Publication statusPublished - 1 Feb 2020

Fingerprint

Lymphatic Vessels
clearances
drainage
Drainage
Optical Coherence Tomography
vessels
stimulation
augmentation
tomography
Lymphatic Endothelium
brain
vasodilation
Nanotubes
endothelium
Brain Diseases
Vasodilation
dextrans
Gold
clearing
cortexes

Bibliographical note

© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Authors and readers may use, reuse, and build upon the article, or use it for text or data mining without asking prior permission from the publisher or the Author(s), as long as the purpose is non-commercial and appropriate attribution is maintained.

Funding: Russian Science Foundation (17-15-01263, 18-15-00172, 19-15-00201).

Cite this

Semyachkina-glushkovskaya, O., Abdurashitov, A., Dubrovsky, A., Klimova, M., Agranovich, I., Terskov, A., ... Kurths, J. (2020). Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions. Biomedical Optics Express, 11(2), 725-734. https://doi.org/10.1364/BOE.383390
Semyachkina-glushkovskaya, Oxana ; Abdurashitov, Arkady ; Dubrovsky, Alexander ; Klimova, Maria ; Agranovich, Ilana ; Terskov, Andrey ; Shirokov, Alexander ; Vinnik, Valeria ; Kuznecova, Anna ; Lezhnev, Nikita ; Blokhina, Inna ; Shnitenkova, Anastassia ; Tuchin, Valery ; Rafailov, Edik ; Kurths, Jurgen. / Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions. In: Biomedical Optics Express. 2020 ; Vol. 11, No. 2. pp. 725-734.
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abstract = "There is a hypothesis that augmentation of the drainage and clearing function of themeningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventingneurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm)of lymphatic drainage and clearance. Our results obtained at optical coherence tomography(OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function ofthe lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation oflymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supportedby confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assumethat PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlyingincreasing the permeability of the lymphatic endothelium that allows molecules transported bythe lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. Thesefindings open new strategies for the stimulation of MLVs functions and non-pharmacologicaltherapy of brain diseases.",
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Semyachkina-glushkovskaya, O, Abdurashitov, A, Dubrovsky, A, Klimova, M, Agranovich, I, Terskov, A, Shirokov, A, Vinnik, V, Kuznecova, A, Lezhnev, N, Blokhina, I, Shnitenkova, A, Tuchin, V, Rafailov, E & Kurths, J 2020, 'Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions', Biomedical Optics Express, vol. 11, no. 2, pp. 725-734. https://doi.org/10.1364/BOE.383390

Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions. / Semyachkina-glushkovskaya, Oxana; Abdurashitov, Arkady; Dubrovsky, Alexander; Klimova, Maria; Agranovich, Ilana; Terskov, Andrey; Shirokov, Alexander; Vinnik, Valeria; Kuznecova, Anna; Lezhnev, Nikita; Blokhina, Inna; Shnitenkova, Anastassia; Tuchin, Valery; Rafailov, Edik; Kurths, Jurgen.

In: Biomedical Optics Express, Vol. 11, No. 2, 01.02.2020, p. 725-734.

Research output: Contribution to journalArticle

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AU - Abdurashitov, Arkady

AU - Dubrovsky, Alexander

AU - Klimova, Maria

AU - Agranovich, Ilana

AU - Terskov, Andrey

AU - Shirokov, Alexander

AU - Vinnik, Valeria

AU - Kuznecova, Anna

AU - Lezhnev, Nikita

AU - Blokhina, Inna

AU - Shnitenkova, Anastassia

AU - Tuchin, Valery

AU - Rafailov, Edik

AU - Kurths, Jurgen

N1 - © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Authors and readers may use, reuse, and build upon the article, or use it for text or data mining without asking prior permission from the publisher or the Author(s), as long as the purpose is non-commercial and appropriate attribution is maintained. Funding: Russian Science Foundation (17-15-01263, 18-15-00172, 19-15-00201).

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Semyachkina-glushkovskaya O, Abdurashitov A, Dubrovsky A, Klimova M, Agranovich I, Terskov A et al. Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions. Biomedical Optics Express. 2020 Feb 1;11(2):725-734. https://doi.org/10.1364/BOE.383390