Photodynamic opening of blood-brain barrier

Oxana Semyachkina-glushkovskaya; Jürgen Kurths; Ekaterina Borisova; Sergei Sokolovski; Vanya Mantareva; Ivan Angelov; Alexander Shirokov; Nikita Navolokin; Natalia Shushunova; Alexander Khorovodov; Maria Ulanova; Madina Sagatova; Ilana Agranivich; Olga Sindeeva; Artem Gekalyuk; Anastasiya Bodrova; Edik Rafailov

doi:10.1364/BOE.8.005040

Photodynamic opening of blood-brain barrier

Oxana Semyachkina-glushkovskaya, Jürgen Kurths, Ekaterina Borisova, Sergei Sokolovski, Vanya Mantareva, Ivan Angelov, Alexander Shirokov, Nikita Navolokin, Natalia Shushunova, Alexander Khorovodov, Maria Ulanova, Madina Sagatova, Ilana Agranivich, Olga Sindeeva, Artem Gekalyuk, Anastasiya Bodrova, Edik Rafailov

Aston Institute of Photonic Technologies (AiPT)

Research output: Contribution to journal › Article › peer-review

Abstract

Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 J/cm2 ) and photosensitizer (5-aminolevulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found that the optimal PDT for the reversible opening of the BBB is 15 J/cm2 and 5- ALA, 20 mg/kg, exhibiting brain tissues recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues. These results can be an informative platform
for further studies of new strategies in brain drug delivery and for better understanding of
mechanisms underlying cerebrovascular effects of PDT-related fluorescence guided resection
of brain tumor

Original language	English
Pages (from-to)	5040
Journal	Biomedical Optics Express
Volume	8
Issue number	11
Early online date	17 Oct 2017
DOIs	https://doi.org/10.1364/BOE.8.005040
Publication status	Published - 17 Oct 2017

Keywords

Medical optics and biotechnology
Medical and biological imaging
Blood or tissue constituent monitoring
Functional monitoring and imaging

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Photodynamic opening of blood-brain barrierFinal published version, 2.62 MBLicence: Other

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Semyachkina-glushkovskaya, O., Kurths, J., Borisova, E., Sokolovski, S., Mantareva, V., Angelov, I., Shirokov, A., Navolokin, N., Shushunova, N., Khorovodov, A., Ulanova, M., Sagatova, M., Agranivich, I., Sindeeva, O., Gekalyuk, A., Bodrova, A., & Rafailov, E. (2017). Photodynamic opening of blood-brain barrier. Biomedical Optics Express, 8(11), 5040. https://doi.org/10.1364/BOE.8.005040

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title = "Photodynamic opening of blood-brain barrier",

abstract = "Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 J/cm2 ) and photosensitizer (5-aminolevulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found that the optimal PDT for the reversible opening of the BBB is 15 J/cm2 and 5- ALA, 20 mg/kg, exhibiting brain tissues recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues. These results can be an informative platformfor further studies of new strategies in brain drug delivery and for better understanding ofmechanisms underlying cerebrovascular effects of PDT-related fluorescence guided resectionof brain tumor",

keywords = "Medical optics and biotechnology, Medical and biological imaging, Blood or tissue constituent monitoring, Functional monitoring and imaging",

author = "Oxana Semyachkina-glushkovskaya and J{\"u}rgen Kurths and Ekaterina Borisova and Sergei Sokolovski and Vanya Mantareva and Ivan Angelov and Alexander Shirokov and Nikita Navolokin and Natalia Shushunova and Alexander Khorovodov and Maria Ulanova and Madina Sagatova and Ilana Agranivich and Olga Sindeeva and Artem Gekalyuk and Anastasiya Bodrova and Edik Rafailov",

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Semyachkina-glushkovskaya, O, Kurths, J, Borisova, E, Sokolovski, S, Mantareva, V, Angelov, I, Shirokov, A, Navolokin, N, Shushunova, N, Khorovodov, A, Ulanova, M, Sagatova, M, Agranivich, I, Sindeeva, O, Gekalyuk, A, Bodrova, A & Rafailov, E 2017, 'Photodynamic opening of blood-brain barrier', Biomedical Optics Express, vol. 8, no. 11, pp. 5040. https://doi.org/10.1364/BOE.8.005040

TY - JOUR

T1 - Photodynamic opening of blood-brain barrier

AU - Semyachkina-glushkovskaya, Oxana

AU - Kurths, Jürgen

AU - Borisova, Ekaterina

AU - Sokolovski, Sergei

AU - Mantareva, Vanya

AU - Angelov, Ivan

AU - Shirokov, Alexander

AU - Navolokin, Nikita

AU - Shushunova, Natalia

AU - Khorovodov, Alexander

AU - Ulanova, Maria

AU - Sagatova, Madina

AU - Agranivich, Ilana

AU - Sindeeva, Olga

AU - Gekalyuk, Artem

AU - Bodrova, Anastasiya

AU - Rafailov, Edik

PY - 2017/10/17

Y1 - 2017/10/17

N2 - Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 J/cm2 ) and photosensitizer (5-aminolevulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found that the optimal PDT for the reversible opening of the BBB is 15 J/cm2 and 5- ALA, 20 mg/kg, exhibiting brain tissues recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues. These results can be an informative platformfor further studies of new strategies in brain drug delivery and for better understanding ofmechanisms underlying cerebrovascular effects of PDT-related fluorescence guided resectionof brain tumor

AB - Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 J/cm2 ) and photosensitizer (5-aminolevulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found that the optimal PDT for the reversible opening of the BBB is 15 J/cm2 and 5- ALA, 20 mg/kg, exhibiting brain tissues recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues. These results can be an informative platformfor further studies of new strategies in brain drug delivery and for better understanding ofmechanisms underlying cerebrovascular effects of PDT-related fluorescence guided resectionof brain tumor

KW - Medical optics and biotechnology

KW - Medical and biological imaging

KW - Blood or tissue constituent monitoring

KW - Functional monitoring and imaging

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DO - 10.1364/BOE.8.005040

M3 - Article

SN - 2156-7085

VL - 8

SP - 5040

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 11

ER -

Photodynamic opening of blood-brain barrier

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