Photodynamic opening of blood-brain barrier

Oxana Semyachkina-glushkovskaya, Jürgen Kurths, Ekaterina Borisova, Sergei Sokolovski, Vanya Mantareva, Ivan Angelov, Alexander Shirokov, Nikita Navolokin, Natalia Shushunova, Alexander Khorovodov, Maria Ulanova, Madina Sagatova, Ilana Agranivich, Olga Sindeeva, Artem Gekalyuk, Anastasiya Bodrova, Edik Rafailov

Research output: Contribution to journalArticlepeer-review

Abstract

Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 J/cm2 ) and photosensitizer (5-aminolevulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found that the optimal PDT for the reversible opening of the BBB is 15 J/cm2 and 5- ALA, 20 mg/kg, exhibiting brain tissues recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues. These results can be an informative platform
for further studies of new strategies in brain drug delivery and for better understanding of
mechanisms underlying cerebrovascular effects of PDT-related fluorescence guided resection
of brain tumor
Original languageEnglish
Pages (from-to)5040
JournalBiomedical Optics Express
Volume8
Issue number11
Early online date17 Oct 2017
DOIs
Publication statusPublished - 17 Oct 2017

Keywords

  • Medical optics and biotechnology
  • Medical and biological imaging
  • Blood or tissue constituent monitoring
  • Functional monitoring and imaging

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