Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

Oxana Semyachkina-Glushkovskaya; Ivan Fedosov; Alexander Shirokov; Elena Vodovozova; Anna Alekseeva; Alexandr Khorovodov; Inna Blokhina; Andrey Terskov; Aysel Mamedova; Maria Klimova; Alexander Dubrovsky; Vasily Ageev; Ilana Agranovich; Valeria Vinnik; Anna Tsven; Sergey Sokolovski; Edik Rafailov; Thomas Penzel; Jürgen Kurths

doi:10.1515/nanoph-2021-0212

Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

Oxana Semyachkina-Glushkovskaya, Ivan Fedosov, Alexander Shirokov, Elena Vodovozova, Anna Alekseeva, Alexandr Khorovodov, Inna Blokhina, Andrey Terskov, Aysel Mamedova, Maria Klimova, Alexander Dubrovsky, Vasily Ageev, Ilana Agranovich, Valeria Vinnik, Anna Tsven, Sergey Sokolovski, Edik Rafailov, Thomas Penzel, Jürgen Kurths

Research output: Contribution to journal › Article › peer-review

Abstract

The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic "smart"delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas.

Original language	English
Article number	0212
Pages (from-to)	3215-3227
Number of pages	13
Journal	Nanophotonics
Volume	10
Issue number	12
Early online date	8 Jul 2021
DOIs	https://doi.org/10.1515/nanoph-2021-0212
Publication status	Published - 2 Sept 2021

Bibliographical note

© 2021 Oxana Semyachkina-Glushkovskaya et al., published by De Gruyter. This work is licensed under the Creative Commons
Attribution 4.0 International License.

Funding: S.-G.O., I.V., A.K., I.B., A.T., A.M., M.K.,
A.D., V.A., I.A., V.V., A.T., T.P., and J.K. were supported by
RF Governmental Grant № 075-15-2019-1885, Grant from
RSF № 20-15-00090 and 19-15-00201, Grant from RFBR 19-
515-55016 China a, 20-015-00308-a. E.R. and S.S. gratefully
acknowledge funding from EU’s H2020 FET OPEN
NEUROPA project under Grant Agreement No. 863214.

Keywords

glioma
liposomes
lymphatic backroad to the brain
photostimulation
rats

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10.1515/nanoph-2021-0212Licence: CC BY 3.0

Photomodulation of lymphatic delivery of liposomes to the brain
© 2021 Oxana Semyachkina-Glushkovskaya et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution 4.0 International License.
Final published version, 3.8 MBLicence: CC BY 3.0

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Semyachkina-Glushkovskaya, O., Fedosov, I., Shirokov, A., Vodovozova, E., Alekseeva, A., Khorovodov, A., Blokhina, I., Terskov, A., Mamedova, A., Klimova, M., Dubrovsky, A., Ageev, V., Agranovich, I., Vinnik, V., Tsven, A., Sokolovski, S., Rafailov, E., Penzel, T., & Kurths, J. (2021). Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy. Nanophotonics, 10(12), 3215-3227. Article 0212. https://doi.org/10.1515/nanoph-2021-0212

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Semyachkina-Glushkovskaya, O, Fedosov, I, Shirokov, A, Vodovozova, E, Alekseeva, A, Khorovodov, A, Blokhina, I, Terskov, A, Mamedova, A, Klimova, M, Dubrovsky, A, Ageev, V, Agranovich, I, Vinnik, V, Tsven, A, Sokolovski, S , Rafailov, E, Penzel, T & Kurths, J 2021, 'Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy', Nanophotonics, vol. 10, no. 12, 0212, pp. 3215-3227. https://doi.org/10.1515/nanoph-2021-0212

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T1 - Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

AU - Semyachkina-Glushkovskaya, Oxana

AU - Fedosov, Ivan

AU - Shirokov, Alexander

AU - Vodovozova, Elena

AU - Alekseeva, Anna

AU - Khorovodov, Alexandr

AU - Blokhina, Inna

AU - Terskov, Andrey

AU - Mamedova, Aysel

AU - Klimova, Maria

AU - Dubrovsky, Alexander

AU - Ageev, Vasily

AU - Agranovich, Ilana

AU - Vinnik, Valeria

AU - Tsven, Anna

AU - Sokolovski, Sergey

AU - Rafailov, Edik

AU - Penzel, Thomas

AU - Kurths, Jürgen

N1 - © 2021 Oxana Semyachkina-Glushkovskaya et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution 4.0 International License. Funding: S.-G.O., I.V., A.K., I.B., A.T., A.M., M.K., A.D., V.A., I.A., V.V., A.T., T.P., and J.K. were supported by RF Governmental Grant № 075-15-2019-1885, Grant from RSF № 20-15-00090 and 19-15-00201, Grant from RFBR 19- 515-55016 China a, 20-015-00308-a. E.R. and S.S. gratefully acknowledge funding from EU’s H2020 FET OPEN NEUROPA project under Grant Agreement No. 863214.

PY - 2021/9/2

Y1 - 2021/9/2

N2 - The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic "smart"delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas.

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KW - glioma

KW - liposomes

KW - lymphatic backroad to the brain

KW - photostimulation

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Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

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