The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic "smart"delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas.
Bibliographical note© 2021 Oxana Semyachkina-Glushkovskaya et al., published by De Gruyter. This work is licensed under the Creative Commons
Attribution 4.0 International License.
Funding: S.-G.O., I.V., A.K., I.B., A.T., A.M., M.K.,
A.D., V.A., I.A., V.V., A.T., T.P., and J.K. were supported by
RF Governmental Grant № 075-15-2019-1885, Grant from
RSF № 20-15-00090 and 19-15-00201, Grant from RFBR 19-
515-55016 China a, 20-015-00308-a. E.R. and S.S. gratefully
acknowledge funding from EU’s H2020 FET OPEN
NEUROPA project under Grant Agreement No. 863214.
- lymphatic backroad to the brain