Abstract
The application of pharmacokinetic modelling within the drug development field essentially allows one to develop a quantitative description of the temporal behaviour of a compound of interest at a tissue/organ level, by identifying and defining relationships between a dose of a drug and dependent variables. In order to understand and characterise the pharmacokinetics of a drug, it is often helpful to employ pharmacokinetic modelling using empirical or mechanistic approaches. Pharmacokinetic models can be developed within mathematical and statistical commercial software such as MATLAB using traditional mathematical and computation coding, or by using the Simbiology Toolbox available within MATLAB for a graphical user interface approach to developing pharmacokinetic (PBPK) models. For formulations dosed orally, a prerequisite for clinical activity is the entry of the drug into the systemic circulation.
| Original language | English |
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| Title of host publication | Computational pharmaceutics |
| Subtitle of host publication | application of molecular modeling in drug delivery |
| Editors | Defang Ouyang, Sean C. Smith |
| Publisher | Wiley |
| Pages | 263-291 |
| Number of pages | 29 |
| ISBN (Print) | 978-1-118573-98-3, 978-1-118573-99-0 |
| DOIs | |
| Publication status | Published - 29 Jun 2015 |