Pioglitazone

Caroline Day*, Clifford J. Bailey

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Pioglitazone is a thiazolidinedione (TZD) antihyperglycemic agent introduced in 1999 for the treatment of type 2 (non-insulin dependent) diabetes mellitus. Another TZD, rosiglitazone, is also used in the treatment of type 2 diabetes. Troglitazone has been withdrawn from clinical use, and other TZDs, such as ciglitazone, have not proceeded into clinical use. Pioglitazone, like other TZDs, improves insulin action mainly by activation of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Peroxisome proliferator-activated receptor-gamma is most strongly expressed in adipose tissue and weakly expressed in liver and skeletal muscle, and activation of PPAR-gammain these tissues reinforces the effects of insulin. Pioglitazone may exert effects on other tissues that express PPAR-gamma ..... © 2007

Original languageEnglish
Title of host publicationxPharm
Subtitle of host publicationthe comprehensive pharmacology reference
EditorsS.J. Enna, David B. Bylund
PublisherElsevier
Number of pages4
ISBN (Print)978-0-08-055232-3
DOIs
Publication statusPublished - 1 Dec 2011

Fingerprint Dive into the research topics of 'Pioglitazone'. Together they form a unique fingerprint.

  • Research Output

    • 6 Chapter (peer-reviewed)

    Biguanides

    Day, C. & Bailey, C. J., Feb 2011, xPharm: the comprehensive pharmacology reference. Enna, S. J. & Bylund, D. B. (eds.). Elsevier, 3 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  • Ciglitazone

    Day, C. & Bailey, C. J., Feb 2011, xPharm: the comprehensive pharmacology reference. Enna, S. J. & Bylund, D. B. (eds.). Elsevier, 2 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  • Metformin

    Day, C. & Bailey, C. J., 1 Dec 2011, xPharm: the comprehensive pharmacology reference. Enna, S. J. & Bylund, D. B. (eds.). Elsevier, 4 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  • Cite this

    Day, C., & Bailey, C. J. (2011). Pioglitazone. In S. J. Enna, & D. B. Bylund (Eds.), xPharm: the comprehensive pharmacology reference Elsevier. https://doi.org/10.1016/B978-008055232-3.62424-9