Pituitary volume in patients with bipolar disorder and their first-degree relatives

Tsutomu Takahashi, Mark Walterfang, Stephen J. Wood, Matthew J. Kempton, Jigar Jogia, Valentina Lorenzetti, Bridget Soulsby, Michio Suzuki, Dennis Velakoulis, Christos Pantelis, Sophia Frangou

Research output: Contribution to journalArticle

Abstract

Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been reported in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have yielded inconsistent findings. In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown. Method: We used MRI to investigate the pituitary volume in 29 remitted patients with BD, 49 of their first-degree relatives (of whom 15 had a diagnosis of Major Depressive Disorder), and 52 age- and gender-matched healthy controls. Results: BD patients had a significantly larger pituitary volume compared with their relatives and healthy controls. Pituitary volume did not differ between controls and healthy relatives or relatives diagnosed with major depression. Limitations: Direct measures of HPA function (i.e., hormonal levels) were not available. Conclusions: These findings suggest that enlarged pituitary volume is associated with disease expression but not genetic susceptibility to BD.
Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalJournal of Affective Disorders
Volume124
Issue number3
DOIs
Publication statusPublished - Aug 2010

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Bipolar Disorder
Magnetic Resonance Imaging
Major Depressive Disorder
Pituitary Gland
Genetic Predisposition to Disease
Depression

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Takahashi, T., Walterfang, M., Wood, S. J., Kempton, M. J., Jogia, J., Lorenzetti, V., ... Frangou, S. (2010). Pituitary volume in patients with bipolar disorder and their first-degree relatives. Journal of Affective Disorders, 124(3), 256-261. https://doi.org/10.1016/j.jad.2009.12.002
Takahashi, Tsutomu ; Walterfang, Mark ; Wood, Stephen J. ; Kempton, Matthew J. ; Jogia, Jigar ; Lorenzetti, Valentina ; Soulsby, Bridget ; Suzuki, Michio ; Velakoulis, Dennis ; Pantelis, Christos ; Frangou, Sophia. / Pituitary volume in patients with bipolar disorder and their first-degree relatives. In: Journal of Affective Disorders. 2010 ; Vol. 124, No. 3. pp. 256-261.
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Takahashi, T, Walterfang, M, Wood, SJ, Kempton, MJ, Jogia, J, Lorenzetti, V, Soulsby, B, Suzuki, M, Velakoulis, D, Pantelis, C & Frangou, S 2010, 'Pituitary volume in patients with bipolar disorder and their first-degree relatives', Journal of Affective Disorders, vol. 124, no. 3, pp. 256-261. https://doi.org/10.1016/j.jad.2009.12.002

Pituitary volume in patients with bipolar disorder and their first-degree relatives. / Takahashi, Tsutomu; Walterfang, Mark; Wood, Stephen J.; Kempton, Matthew J.; Jogia, Jigar; Lorenzetti, Valentina; Soulsby, Bridget; Suzuki, Michio; Velakoulis, Dennis; Pantelis, Christos; Frangou, Sophia.

In: Journal of Affective Disorders, Vol. 124, No. 3, 08.2010, p. 256-261.

Research output: Contribution to journalArticle

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AU - Wood, Stephen J.

AU - Kempton, Matthew J.

AU - Jogia, Jigar

AU - Lorenzetti, Valentina

AU - Soulsby, Bridget

AU - Suzuki, Michio

AU - Velakoulis, Dennis

AU - Pantelis, Christos

AU - Frangou, Sophia

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Takahashi T, Walterfang M, Wood SJ, Kempton MJ, Jogia J, Lorenzetti V et al. Pituitary volume in patients with bipolar disorder and their first-degree relatives. Journal of Affective Disorders. 2010 Aug;124(3):256-261. https://doi.org/10.1016/j.jad.2009.12.002