Plasma irisin levels predict telomere length in healthy adults

Karan S. Rana, Muhammad Arif, Eric J. Hill, Sarah Aldred, David A. Nagel, Alan Nevill, Harpal S. Randeva, Clifford J. Bailey, Srikanth Bellary, James E. Brown

Research output: Contribution to journalArticle

Abstract

The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43∈±∈15.8 years, BMI 24.3∈±∈2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p∈<∈0.001), height (p∈=∈0.045), total body fat percentage (p∈=∈0.031), abdominal fat percentage (p∈=∈0.038) , visceral fat level (p∈<∈0.001), plasma leptin (p∈=∈0.029) and plasma irisin (p∈=∈0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b∈=∈-0.00735, p∈=∈0.001) and plasma irisin levels (b∈=∈0.04527, p∈=∈0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process. © 2014 The Author(s).

LanguageEnglish
Pages995-1001
Number of pages7
JournalAge
Volume36
Issue number2
Early online date29 Jan 2014
DOIs
Publication statusPublished - Apr 2014

Fingerprint

Telomere
Body Composition
Adipose Tissue
Abdominal Fat
Intra-Abdominal Fat
Leptin
Energy Metabolism
Mammals
Blood Cells
Skeletal Muscle
Regression Analysis
Hormones
Exercise
Food

Bibliographical note

Creative Commons Attribution (CC BY 4.0) license. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the original author and source are properly attributed.

Keywords

  • adipose tissue
  • ageing
  • body composition
  • irisin
  • muscle
  • telomere length

Cite this

Rana, Karan S. ; Arif, Muhammad ; Hill, Eric J. ; Aldred, Sarah ; Nagel, David A. ; Nevill, Alan ; Randeva, Harpal S. ; Bailey, Clifford J. ; Bellary, Srikanth ; Brown, James E. / Plasma irisin levels predict telomere length in healthy adults. In: Age. 2014 ; Vol. 36, No. 2. pp. 995-1001.
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Plasma irisin levels predict telomere length in healthy adults. / Rana, Karan S.; Arif, Muhammad; Hill, Eric J.; Aldred, Sarah; Nagel, David A.; Nevill, Alan; Randeva, Harpal S.; Bailey, Clifford J.; Bellary, Srikanth; Brown, James E.

In: Age, Vol. 36, No. 2, 04.2014, p. 995-1001.

Research output: Contribution to journalArticle

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T1 - Plasma irisin levels predict telomere length in healthy adults

AU - Rana, Karan S.

AU - Arif, Muhammad

AU - Hill, Eric J.

AU - Aldred, Sarah

AU - Nagel, David A.

AU - Nevill, Alan

AU - Randeva, Harpal S.

AU - Bailey, Clifford J.

AU - Bellary, Srikanth

AU - Brown, James E.

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N2 - The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43∈±∈15.8 years, BMI 24.3∈±∈2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p∈<∈0.001), height (p∈=∈0.045), total body fat percentage (p∈=∈0.031), abdominal fat percentage (p∈=∈0.038) , visceral fat level (p∈<∈0.001), plasma leptin (p∈=∈0.029) and plasma irisin (p∈=∈0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b∈=∈-0.00735, p∈=∈0.001) and plasma irisin levels (b∈=∈0.04527, p∈=∈0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process. © 2014 The Author(s).

AB - The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43∈±∈15.8 years, BMI 24.3∈±∈2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p∈<∈0.001), height (p∈=∈0.045), total body fat percentage (p∈=∈0.031), abdominal fat percentage (p∈=∈0.038) , visceral fat level (p∈<∈0.001), plasma leptin (p∈=∈0.029) and plasma irisin (p∈=∈0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b∈=∈-0.00735, p∈=∈0.001) and plasma irisin levels (b∈=∈0.04527, p∈=∈0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process. © 2014 The Author(s).

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KW - ageing

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