Point of use production of liposomal solubilised products

Swapnil Khadke, Peter Stone, Oleksiy Rozhin, Jerome Kroonen, Yvonne Perrie

Research output: Contribution to journalArticle

Abstract

With the progression towards personalised and age-appropriate medicines, the production of drug loaded liposomes at the point of care would be highly desirable. In particular, liposomal solubilisation agents that can be produced rapidly and easily would provide a new option in personalised medicines. Such a process could also be used as a rapid tool for the formulation and pre-clinical screening of low soluble drugs. Within this paper, we outline a novel easy-to-use production method for point of use production of liposome solubilised drugs. Our results demonstrate that pre-formed multilamellar liposomes, stored in a fresh or frozen format, can be bilayer loaded with low solubility drugs using a simple bath sonication process. Sonication is undertaken in a sealed vial allowing the contents to remain sterile. Liposomes around 100 nm were prepared and these liposomes were able to increase the amount of drug dissolved by up to 10 fold. These liposomal solubilisation agents were stable in terms of size and drug solubilisation for up to 8 days when stored in the fridge making them an easy to use and robust small-scale tool for drug solubilisation.
Original languageEnglish
JournalInternational Journal of Pharmaceutics
Early online date8 Dec 2017
DOIs
Publication statusPublished - 8 Dec 2017

Fingerprint

Liposomes
Pharmaceutical Preparations
Sonication
Point-of-Care Systems
Precision Medicine
Baths
Solubility

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/.

Funding: BBSRC (Industrial Case Award BB/L017245/1) and Diagenode S.A.

Keywords

  • liposomes; solubilisation; low solubility drugs; sonication; personalised formulation;
  • rapid screening

Cite this

Khadke, Swapnil ; Stone, Peter ; Rozhin, Oleksiy ; Kroonen, Jerome ; Perrie, Yvonne. / Point of use production of liposomal solubilised products. In: International Journal of Pharmaceutics. 2017.
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Point of use production of liposomal solubilised products. / Khadke, Swapnil; Stone, Peter; Rozhin, Oleksiy; Kroonen, Jerome; Perrie, Yvonne.

In: International Journal of Pharmaceutics, 08.12.2017.

Research output: Contribution to journalArticle

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